Washington Obstetric-Fetal Pharmacology Research Unit

华盛顿产胎儿药理学研究单位

• 批准号: 7073996
• 负责人: MENACHEM MIODOVNIK
• 金额: $ 60万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7073996
• 关键词: anticonvulsants; behavioral /social science research tag; brain disorder chemotherapy; child (0-11); clinical research; clinical trials; computer simulation; cooperative study; developmental neurobiology; drug administration rate /duration; embryo /fetus drug adverse effect; epilepsy; female; human pregnant subject; human subject; human therapy evaluation; laboratory rat; magnetic resonance imaging; neuroanatomy; neuropharmacology; neuropsychology; neurotoxicology; patient oriented research; pharmacokinetics; pregnancy; women' s health

DESCRIPTION (provided by applicant): The Washington Obstetric Pharmacology Research Unit (WOPRU) represents a collaboration among two universities and four medical centers in the nation's capitol that is uniquely positioned to use population pharmacokinetic, pharmacokinetic-pharmacodynamic, clinical trials simulation, cutting edge in vivo and in vitro techniques to assess clinical pharmacology of important therapeutic agents and their effects in pregnant women and their offspring. Specifically, the WOPRU combines the basic research resources of Georgetown University (GU) (lead agency) and George Washington University (GWU) with the clinical strengths of MedStar Health (Washington Hospital Center [WHC] and Georgetown University Hospital [GUH]), GWU Hospital, and Children's National Medical Center (CNMC). Our hospitals are strategically placed throughout the DC metropolitan area, and are closely associated with the respective surrounding communities. The WOPRU obstetricians deliver over 7,000 babies from women who represent a broad spectrum of social, economic, ethnic, racial and cultural backgrounds with a large proportion of these pregnancies being high risk. The WOPRU institutions have an excellent track record of providing care and recruiting patients into clinical trials from our diverse community. The faculty of the WOPRU represent a team of highly motivated basic scientists and clinical investigators who are enthusiastically approaching the prospect of becoming a new center for OPRU. They are experienced investigators in a multitude of basic science and clinical disciplines with a unique combination of strengths in pharmacometrics, pharmacodynamics, pharmacogenetics, drug metabolism, therapeutic drug monitoring, proteomics, genomics and biostatistics in conjunction with significant experience in multi-center clinical trials. The administration, and the basic science and clinical investigators of the WOPRU institutions are unanimous in their eagerness to support and participate in the future OPRU network.

描述（由申请人提供）：华盛顿产科药理学研究部（WOPRU）代表了该国大厦的两所大学和四个医疗中心之间的合作，它具有独特的位置，可以使用种群药代动力学的药代动力学，药代动力学 - 药物动力学，临床试验，以临床和临床上的临床效果和体外的技术影响，并评估其体内的临床效果，并具有重要的影响力。后代。具体而言，Wopru将乔治敦大学（GU）（牵头机构）和乔治华盛顿大学（GWU）的基础研究资源与MedStar Health（华盛顿医院中心[WHC]和Georgetown University Hospital [GUH]），GWU医院和儿童国家医疗中心（CNMC）的临床优势结合在一起。 我们的医院在整个DC都会区都有战略性地放置，并且与各自的社区密切相关。沃普鲁（Wopru）产科医生从妇女中分娩了7,000多名婴儿，这些妇女代表着广泛的社会，经济，种族，种族和文化背景，其中很大一部分这些怀孕是高风险。 Wopru机构在我们多样化社区的临床试验中提供护理和招募患者的良好记录。 Wopru的教职员工代表了一个积极进取的基础科学家和临床研究人员，他们热情地接近成为OPRU的新中心的前景。他们是许多基础科学和临床学科的经验丰富的研究者，在药物计量学，药效学，药物遗传学，药物代谢，治疗药物监测，蛋白质组学，基因组学和生物统计学以及多种临床临床试验中的丰富经验中，具有独特的优势组合。 Wopru机构的政府以及基础科学和临床研究者渴望支持和参与未来的OPRU网络。