Effects of Anxiety on Interhemispheric Processing

焦虑对半球间加工的影响

基本信息

批准号：
6754667
负责人：
REBECCA J COMPTON
金额：
$ 18.49万
依托单位：
HAVERFORD COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6754667
关键词：
angers anxiety clinical research cognition communication emotions evoked potentials human subject interhemispheric transfer neural information processing neuropsychology psychological stressor

项目摘要

DESCRIPTION (provided by applicant): The present investigation examines the interhemispheric transfer of emotional and non-emotional information in anxious individuals. Anxiety is known to influence cognitive functioning, resulting in both overall cognitive inefficiency and selective biases to attend to threatening stimuli. Neural mechanisms for these cognitive deficits are currently not well understood. Our prior work using behavioral paradigms indicates that anxious and non-anxious individuals differ in interhemispheric communication. Specifically, anxious individuals do not appear to exchange information between the hemispheres as effectively as do non-anxious individuals. Further, anxious individuals appear to shift processing priorities to favor the interhemispheric exchange of threatening information, relative to positive information. These data indicate that interhemispheric communication may serve as a model system for understanding the cognitive deficits characteristic of anxiety. The present series of studies applies event-related potential (ERP) measures of interhemispheric transfer to study these issues, overcoming limitations of the behavioral methodology used to date. Three specific predictions are tested: (1) that interhemispheric transfer of non-emotional information is slowed in anxious individuals; (2) that interhemispheric transfer of threatening emotional information is relatively speeded in anxious individuals; and (3) that interhemispheric transfer of threatening emotional information is asymmetrically speeded from the left hemisphere to the right hemisphere, which is specialized for processing emotional cues. These predictions are tested in three studies that measure interhemispheric transmission time when subjects view neutral stimuli (Study 1), emotional faces (Study 2), and emotional words (Study 3). Application of the ERP methodology for measuring interhemispheric transmission is expected to produce a detailed picture of how emotional relevance affects the spread of information from one hemisphere to another.

描述（由申请人提供）：本研究检查焦虑个体情绪和非情绪信息的半球间传递。众所周知，焦虑会影响认知功能，导致整体认知效率低下和对威胁性刺激的选择性偏见。这些认知缺陷的神经机制目前尚不清楚。我们之前使用行为范式的研究表明，焦虑和非焦虑的个体在大脑半球间的沟通上存在差异。具体来说，焦虑的人似乎不像不焦虑的人那样有效地在半球之间交换信息。此外，相对于积极信息，焦虑的个体似乎会改变处理优先级，以支持威胁性信息的半球间交换。这些数据表明，大脑半球间的交流可以作为理解焦虑的认知缺陷特征的模型系统。本系列研究应用半球间转移的事件相关电位（ERP）测量来研究这些问题，克服了迄今为止使用的行为方法的局限性。测试了三个具体的预测：（1）焦虑的个体中非情绪信息的半球间传递会减慢； (2) 在焦虑的个体中，威胁性情绪信息的半球间传递相对较快；（3）威胁情绪信息的半球间传输从左半球到专门处理情绪线索的右半球的速度不对称。这些预测在三项研究中进行了测试，这些研究测量了受试者观看中性刺激（研究 1）、情绪面孔（研究 2）和情绪词（研究 3）时的半球间传输时间。应用 ERP 方法来测量半球间的传输预计将详细描述情绪相关性如何影响信息从一个半球到另一个半球的传播。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Take it to the bridge: an interhemispheric processing advantage for emotional faces.

把它带到桥上：半球间处理情绪面孔的优势。

DOI：
发表时间：
2005-06
期刊：
影响因子：
0
作者：
Compton, Rebecca J;Feigenson, Keith;Widick, Page
通讯作者：
Widick, Page

Trouble crossing the bridge: altered interhemispheric communication of emotional images in anxiety.

过桥困难：焦虑中情绪图像的半球间交流发生改变。

DOI：
发表时间：
2008-10
期刊：
影响因子：
0
作者：
Compton, Rebecca J;Carp, Joshua;Chaddock, Laura;Fineman, Stephanie L;Quandt, Lorna C;Ratliff, Jeffrey B
通讯作者：
Ratliff, Jeffrey B

Anxiety and error monitoring: increased error sensitivity or altered expectations?

焦虑和错误监控：错误敏感性增加或期望改变？

DOI：
发表时间：
2007-08
期刊：
影响因子：
2.5
作者：
Compton, Rebecca J;Carp, Joshua;Chaddock, Laura;Fineman, Stephanie L;Quandt, Lorna C;Ratliff, Jeffrey B
通讯作者：
Ratliff, Jeffrey B

Inter-hemispheric interaction facilitates face processing.

半球间的相互作用有利于面部处理。