High Performance Mass Spectrometer for Proteomics

用于蛋白质组学的高性能质谱仪

• 批准号: 6877290
• 负责人: John R Yates III
• 金额: $ 50万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877290
• 关键词: biomedical equipment purchase; biotechnology; electrospray ionization mass spectrometry; interferometry; liquid chromatography mass spectrometry; protein quantitation /detection; protein structure; proteomics

DESCRIPTION (provided by applicant): To support proteomic research at The Scripps Research Institute (TSRI), a linear ion trap-FTICR hybrid mass spectrometer is requested. Projects involving the identification of proteins, protein modifications, protein-cross-linking and protein profiling that will be supported by the instrument are described. The high resolution, high mass accuracy capability of the instrument will impact proteomics research at TSRI by providing high confidence levels in the mass spectrometry data to aid in the identification of modifications and low abundance proteins. The research of 14 Principal Investigators will lie directly supported by the instrument with approximately 270 Investigators at TSRI having access as minor users.

描述（由申请人提供）：为了支持斯克里普斯研究所 (TSRI) 的蛋白质组学研究，需要一台线性离子阱-FTICR 混合质谱仪。描述了该仪器支持的涉及蛋白质鉴定、蛋白质修饰、蛋白质交联和蛋白质分析的项目。该仪器的高分辨率、高质量准确度能力将通过提供高置信度的质谱数据来帮助识别修饰和低丰度蛋白质，从而影响 TSRI 的蛋白质组学研究。该工具将直接支持 14 名主要研究人员的研究，其中 TSRI 的大约 270 名研究人员可以作为次要用户访问。