X-Ray Detector for the Life Sciences CAT at the APS

APS 生命科学 CAT 的 X 射线探测器

• 批准号: 6877407
• 负责人: WAYNE F ANDERSON
• 金额: $ 50万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-15 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877407
• 关键词: biomedical equipment purchase; computed axial tomography; electron crystallography; structural biology

DESCRIPTION (provided by applicant): This proposal requests funds for acquiring state of the art instrumentation for structural biology research on the initial insertion device beamline in the Life Sciences (LS-CAT) sector at the Advanced Photon Source. This beamline will utilize radiation from the first of two (2) undulators that LS-CAT will install and will provide a tunable, high intensity beamline for macromolecular crystallography. Funds for the Phase I construction, which includes this beamline, have already been obtained by LS-CAT and construction is about to begin. It is expected that first use of the beamline will occur in late 2005. The Life Sciences Collaborative Access Team is a consortium of academic and research institutions comprised of Northwestern University, Michigan State University, the University of Michigan, Wayne State University, the Van Andel Institute, the University of Illinois at Urbana-Champaign, and the University of Wisconsin. The investigators participating in LS-CAT are involved in cutting edge structural biology with special emphasis in membrane proteins, multicomponent systems in signaling and protein transport, protein-nucleic acid complexes involved in genome replication, repair, recombination and regulation, and enzymes that are novel targets for mechanistic studies or biotechnology. Many of the researchers associated with LS-CAT have already reached the technical barriers of small crystal size or large unit cells that make access to a dedicated synchrotron source essential to the scientific progress. The instrumentation requested is a large area CCD detector suitable for high resolution studies of individual macromolecules and complexes with large unit cells. The requested detector will have the large surface area, high spatial resolution and rapid read-out that are essential for allowing investigators to tackle increasingly difficult structural problems.

描述（由申请人提供）：该提案要求在高级光子源的生命科学（LS-CAT）扇区中对最初的插入设备梁线（LS-CAT）领域的结构生物学研究获得资金。该梁线将利用LS-CAT将安装的两个（2）个驱动器中的第一个辐射，并将为大分子晶体学提供可调的高强度光束线。 LS-CAT已经获得了I期建筑的资金，其中包括该梁线，即将开始结构。可以预期，梁线的首次使用将于2005年下半年进行。生活科学合作访问团队是由西北大学，密歇根州立大学，密歇根大学，韦恩州立大学，范安德尔大学，范·安德尔研究所，伊利诺伊大学的Urbana-Champaigniagenions of Wisconsins和Wistsonsin的大学组成的学术和研究机构联盟。参与LS-CAT的研究人员参与了尖端结构生物学，在膜蛋白，信号传导和蛋白质转运中的多组分系统，参与基因组复制，修复，重新组合和调节的蛋白质核酸复合物以及是机械研究或生物技术的新靶标的蛋白质核酸复合物以及蛋白质核酸络合物。与LS-CAT相关的许多研究人员已经达到了小晶体大小或大型单元细胞的技术障碍，这些障碍可以进入科学进步必不可少的专用同步加速器源。所请求的仪器是一个大面积的CCD检测器，适用于对单个大分子和大型单元细胞的复合物进行高分辨率研究。所请求的检测器将具有较大的表面积，高空间分辨率和快速读数，这对于允许研究人员能够解决日益困难的结构问题至关重要。