Improving Symptoms in Older Breast Cancer Survivors

改善老年乳腺癌幸存者的症状

• 批准号: 7118248
• 负责人: SUSAN M. HEIDRICH
• 金额: $ 37.63万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7118248
• 关键词: behavioral /social science research tag; belief; breast neoplasms; clinical research; clinical trials; female; human old age (65+); human subject; human therapy evaluation; injury /disease stressor; interview; long term survivor; longitudinal human study; neoplasm /cancer therapy; patient oriented research; psychological aspect of cancer; psychological stressor; quality of life; questionnaires; sign /symptom; stress management; women' s health

DESCRIPTION (provided by applicant): We propose a randomized clinical trial to test the efficacy and durability of an Individualized Representational Intervention (IRIS) to reduce symptom distress and improve quality of life in older breast cancer (BC) survivors. IRIS is conceptually grounded in Donovan and Ward's Representational Approach to Patient Education (Donovan & Ward, 2001; Leventhal, Meyer, & Nerenz, 1980) and extensive preliminary research by the investigators in which beliefs about symptoms and symptom management were identified and an intervention to address these beliefs and improve symptom management was developed. Although 50% of breast cancers are in women over 65, their problems and needs have not been identified or addressed. Older breast cancer survivors face unique challenges because they experience symptoms of their disease and its treatment concurrent with symptoms of age related chronic illnesses, and they may hold beliefs that may function as barriers to effective symptom management. From this perspective, age is the salient context influencing women's experience of breast cancer as well as the dimensions that comprise quality of life. A sample of 207 women, aged 65 and over, and at least three months post-treatment for non-metastatic breast cancer will be randomly assigned to IRIS or Wait-List Control. IRIS is an individualized psychoeducational program delivered by an advanced practice nurse in a face-to-face interview with four telephone reinforcements. Data collection will occur at baseline and two, four, six, eight, and 16 weeks post-intervention using standardized instruments. The specific hypotheses are that IRIS will be superior to wait-list control with respect to symptom distress and quality of life from baseline to post-test and from baseline to follow-up and the effect of IRIS will be mediated by symptom management beliefs and strategies.

描述（由申请人提供）：我们提出了一项随机临床试验，以测试个性化代表性干预（IRIS）的功效和耐用性，以减轻症状困扰并改善老年乳腺癌（BC）幸存者的生活质量。艾里斯（Iris）在多诺万（Donovan）和沃德（Ward）对患者教育的代表性方法上是基础的（Donovan＆Ward，2001; Leventhal，Meyer和Nerenz，1980年）以及研究人员的广泛初步研究，在这些研究中，人们对症状和症状管理的信念得到了识别，并且有一种解决这些信念和改善症状管理的干预措施。尽管有50％的乳腺癌在65岁以上的女性中，但尚未发现或解决她们的问题和需求。老年乳腺癌幸存者面临独特的挑战，因为他们经历了疾病的症状，并且与年龄相关的慢性疾病症状同时进行治疗，并且他们可能会持有可能充当有效症状管理的障碍的信念。从这个角度来看，年龄是影响妇女对乳腺癌的经历以及构成生活质量的尺寸的显着背景。为65岁及65岁以上的207名妇女和非转移性乳腺癌治疗后至少三个月的样本将被随机分配给IRIS或等待名单。艾里斯（Iris）是一项个性化的心理教育计划，由高级实践护士在面对面的四个电话增援部队面对面采访中提供。数据收集将在干预后使用标准化仪器进行干预后的二，四，六，八和16周发生。具体的假设是，在从基线到测试后的症状困扰和生活质量方面，以及从基线到后续行动，IRIS将优于等待名单的控制，并且IRIS的效果将由症状管理信念和策略介导。