LSO Ceramics: A New Scintillator for Medical Radiography

LSO 陶瓷：用于医学放射成像的新型闪烁体

• 批准号: 6692156
• 负责人: ALEXANDER LEMPICKI
• 金额: $ 40万
• 依托单位: ALEM ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-10 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6692156
• 关键词: LSO; Ceramics; New; Scintillator; Medical

DESCRIPTION (provided by applicant): We propose to conduct research and development towards a ceramic scintillator composed of LSO:Ce. It is well known that crystalline LSO is one of the highest performance scintillators in terms of light output and timing. Only one impediment stands in the way of LSO assuming a commanding position in most areas of medical applications: its unacceptably high cost, which is due largely to the very high temperatures necessary to grow the crystals and consequently the very low yield of good crystals (high light output and no afterglow). Having demonstrated in Phase I that an LSO ceramic can be made and that it has an efficiency and decay time comparable to LSO crystals, while carrying the promise of less afterglow, we wish to embark on a program of optimizing the material. One of the essential aspects is to increase the translucency to at least that of another widely used scintillator, namely GOS ceramic. This goal will be achieved through a control of the microstructure of the ceramic, involving methods, which will promote grain growth. We believe that the LSO ceramic will be appropriate in PET imaging, which now primarily uses LSO crystals, resulting in greatly reduced cost. Furthermore we believe that the ceramic will find applications in CT, where increase in speed is currently limited by the longer decay times of Cd tungstate and/or GOS.

描述（由申请人提供）： 我们建议对由LSO:Ce组成的陶瓷闪烁体进行研究和开发。众所周知，晶体 LSO 是光输出和定时方面性能最高的闪烁体之一。只有一个障碍阻碍 LSO 在大多数医疗应用领域占据主导地位：其成本高得令人难以接受，这主要是由于生长晶体所需的温度非常高，因此良好晶体的产量非常低（高晶体）。光输出且无余辉）。 在第一阶段证明了可以制造 LSO 陶瓷，并且它的效率和衰减时间与 LSO 晶体相当，同时有望减少余辉，我们希望着手优化该材料的计划。其中一个重要方面是将半透明度至少提高到另一种广泛使用的闪烁体（即 GOS 陶瓷）的半透明度。这一目标将通过控制陶瓷的微观结构来实现，其中包括促进晶粒生长的方法。 我们相信LSO陶瓷将适用于PET成像，目前PET成像主要使用LSO晶体，从而大大降低了成本。此外，我们相信陶瓷将在 CT 领域得到应用，目前 CT 速度的提高受到钨酸镉和/或 GOS 较长衰减时间的限制。