Anti-inflammatory effects of Bromelain

菠萝蛋白酶的抗炎作用

• 批准号: 7022281
• 负责人: Eric Richard Secor
• 金额: $ 6.23万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-23 至 2007-02-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7022281
• 关键词: alternative medicine; antiinflammatory agents; biotherapeutic agent; cysteine endopeptidases; cytokine; disease /disorder model; dosage; enzyme linked immunosorbent assay; flow cytometry; histology; immunoglobulin E; immunoglobulin G; immunoregulation; laboratory mouse; lung lavage; lymphocyte; nonhuman therapy evaluation; nutrition related tag; ovalbumin; plant extracts; postdoctoral investigator; respiratory disorder; respiratory disorder chemotherapy; respiratory function; spleen

DESCRIPTION (provided by applicant): Investigate the anti-inflammatory (protease and immunoregulatory) effects of Bromelain, a commonly used nutritional supplement, in a mouse model of allergic airway disease. 1. Determine if Bromelain treatment alters lung function and/or pathophysiology in normal naive mice and in mice with OVA-induced allergic airway disease. 2. Investigate the mechanism(s) by which Bromelain treatment affects lung function and/or pathophysiology in normal mice and in mice OVA-induced allergic airway disease.

描述（由申请人提供）： 研究菠萝蛋白酶（一种常用的营养补充剂）在过敏性气道疾病小鼠模型中的抗炎（蛋白酶和免疫调节）作用。 1. 确定菠萝蛋白酶治疗是否会改变正常幼鼠和患有 OVA 诱导的过敏性气道疾病的小鼠的肺功能和/或病理生理学。 2. 研究菠萝蛋白酶治疗影响正常小鼠和小鼠 OVA 诱导的过敏性气道疾病的肺功能和/或病理生理学的机制。

项目成果

Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma.

• DOI: 10.1093/ecam/nel110
• 发表时间: 2008-03
• 期刊: Evidence-based complementary and alternative medicine : eCAM
• 作者: Secor ER;Carson WF;Singh A;Pensa M;Guernsey LA;Schramm CM;Thrall RS
• 通讯作者: Thrall RS

Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin.

在小鼠哮喘模型中，慢性吸入抗原诱导的耐受性不是由内毒素介导的。

• DOI: 10.1016/j.bbadis.2006.02.002
• 发表时间: 2006
• 期刊: Biochimica et biophysica acta
• 作者: Schramm,CM;Guernsey,L;Secor,E;Thrall,RS
• 通讯作者: Thrall,RS