White matter integrity and autonmic stress response

白质完整性和自主应激反应

• 批准号: 7157807
• 负责人: JOHN B WILLIAMSON
• 金额: $ 4.88万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157807
• 关键词: aging; arrhythmia; autonomic nervous system; bioimaging /biomedical imaging; brain morphology; cerebral ischemia /hypoxia; cerebrovascular disorders; cerebrovascular imaging /visualization; clinical research; cognition; cognition disorders; diffusion magnetic resonance imaging; frontal lobe /cortex; heart rate; human old age (65+); human subject; microcirculation; neural degeneration; neural information processing; neuropathology; neuropsychological tests; physiologic stressor; postdoctoral investigator; psychological stressor; stimulus /response; vagus nerve; white matter

DESCRIPTION (provided by applicant): The scientific literature on vascular cognitive impairment (VCI) suggests relative functional deficits in fronto- subcortical networks (FSN). Though not exclusive among dementias to VCI, FSN dysfunction is, perhaps, more prominent in relative severity. Small vessel ischemic disease (SVID), associated with white matter disease (WMD), is one pathway through which VCI may occur. The prominence of white matter in FSN and recent research showing hypoprofusion of prefrontal cortex with WMD anywhere in the brain suggest a logical area of study. The proposed investigation is of autonomic, behavioral, and cognitive functions associated with FSN involvement in SVID patients recruited from an ongoing NIA-funded parent project, which examines risk markers for dementia after stroke. Towards this goal, a program has been designed to provide new training and skills in theories of pathophysiology and cognition in VCI, collection and analysis of data from cognitive, imaging (e.g., Diffusion Tensor Imaging), and autonomic measures (e.g., heart rate variability, respiratory sinus arrhythmia), and conduction of an independent research project synthesizing these skills that will promote the development of an academic research career.

描述（由申请人提供）：关于血管性认知障碍（VCI）的科学文献表明额叶皮质下网络（FSN）存在相对功能缺陷。尽管 FSN 功能障碍并非 VCI 所独有，但 FSN 功能障碍的相对严重程度可能更为突出。与白质疾病 (WMD) 相关的小血管缺血性疾病 (SVID) 是 VCI 发生的途径之一。 FSN 中白质的突出地位以及最近的研究表明，大脑任何地方的大规模杀伤性武器导致前额叶皮层发育不足，这表明了一个合乎逻辑的研究领域。拟议的调查是对与 FSN 参与相关的 SVID 患者的自主、行为和认知功能进行研究，这些患者是从正在进行的 NIA 资助的母项目中招募的，该项目检查中风后痴呆的风险标记。为了实现这一目标，设计了一个计划来提供 VCI 病理生理学和认知理论的新培训和技能，收集和分析来自认知、成像（例如扩散张量成像）和自主测量（例如心率变异性）的数据、呼吸性窦性心律失常），并开展综合这些技能的独立研究项目，这将促进学术研究事业的发展。