Genetic and Environmental Modifiers of Parkinson Disease

帕金森病的遗传和环境调节剂

• 批准号: 7156673
• 负责人: Dana B Hancock
• 金额: $ 2.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156673
• 关键词: clinical research; family; genes; genetics

DESCRIPTION (provided by applicant): Parkinson Disease (PD) affects approximately one million Americans (Olanow et al. 1998). Considering peak incidence occurs between ages 55 and 66 (McDonald et al. 2003) and the U.S. population is aging, PD prevalence and ensuing societal costs are expected to rise. Deciphering the etiology of PD to improve its diagnosis, treatment, and prevention is a societal goal of utmost importance. As genetic and environmental factors have been implicated in the disease process, investigation into genetic susceptibility requires consideration for environmental modifiers. With a large collection of PD families, candidate genes of the nitric oxide synthesizing family will be examined with family-based association tests; associations between PD risk and environmental factors that demonstrate a biologically plausible link to the candidate genes will be assessed; and interactions between the genetic and environmental factors will then be analyzed. Since the most appropriate method for genetic and environmental association and interaction analyses with family- based data is not yet established, an empirical comparison of conditional logistic regression and generalized estimating equations will be performed to propose the most appropriate analytic tool in this context.

描述（由申请人提供）：帕金森病（PD）影响大约一百万美国人（Olanow 等人，1998）。考虑到发病高峰出现在 55 岁至 66 岁之间（McDonald 等人，2003 年）并且美国人口正在老龄化，PD 患病率和随之而来的社会成本预计将会上升。破译帕金森病的病因以改善其诊断、治疗和预防是最重要的社会目标。由于遗传和环境因素与疾病过程有关，因此研究遗传易感性需要考虑环境调节剂。随着PD家族的大量收集，一氧化氮合成家族的候选基因将通过基于家族的关联测试进行检查；将评估PD风险与环境因素之间的关联，这些关联证明与候选基因在生物学上合理的联系；然后将分析遗传因素和环境因素之间的相互作用。由于尚未建立最合适的遗传和环境关联以及与基于家庭的数据的相互作用分析的方法，因此将进行条件逻辑回归和广义估计方程的实证比较，以提出在此背景下最合适的分析工具。