Assessing depression in African American cancer patients

评估非裔美国癌症患者的抑郁症

• 批准号: 7162400
• 负责人: Amy Y Zhang
• 金额: $ 7.73万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-17 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7162400
• 关键词: clinical research; depression; experience; neoplasm /cancer

DESCRIPTION (provided by applicant): African Americans (AA) have the highest incidence and death rates from all cancers in the U.S. Adequate assessment and treatment of depression in AA cancer patients is essential to reduce this unequal burden of cancer and health disparity. Current knowledge of AA cancer patients' depression is extremely limited. A few existing studies suggest inadequate recognition of the extent of depression in this population. Currently no available instrument has been validated for screening depression of AA cancer patients, despite increasing evidence of cultural insensitivity of depression measures for African Americans. It is imperative to develop a culturally sensitive screening instrument for AA cancer patients' depression, in order to provide adequate referral and needed care. The development of this instrument would require a deep understanding of AA depressive experience. This application is the first study of the lived experience of depression in AA cancer patients. It is significant because of the large size of AA cancer population, the need to combat cancer disparity, and its implication for quality of life and long-term survival of AA cancer patients. Using a mixed design, the study will provide baseline knowledge of AA depressive experience and identify AA depressive symptoms as an initial step of the instrument construction. The specific aims are as follows: 1) Describe the meaning and structure of AA depressive experience in the context of living with cancer; 2) Compare depressed and nondepressed AA cancer patients to identify beliefs and attitudes about having cancer, which are associated with depression; and 3) Identify manifestations of AA depression and create a symptom catalogue that can be developed into a culturally sensitive screening instrument for assessing AA cancer patient's depression in a future study. The interview sample will consist of 80 cancer patients-20 patients in each of four groups: 3 AA groups and a white group consisting of two subgroups, varying by degree of depression. The group members will be further stratified by age and cancer diagnosis for an unstructured individual interview that will be audiotaped, transcribed, and analyzed verbatim. In the validation phase, an additional 10 AA cancer patients will be recruited to determine the credibility of study outcomes. Qualitative data analysis using the NUDIST software will identify themes and their relationships to describe: 1) meanings and structure of the lived depressive experience of AA cancer patients; 2) beliefs and attitudes about having cancer; and 3) self- explanations of depressive experiences. The mixed method analysis using statistical and qualitative methods will be used to identify AA depressive symptoms. Consequently, a symptom catalogue that inventories the identified AA depressive symptoms will be constructed so that a culturally sensitive screening instrument for assessing depression in AA cancer patients can be developed in a future study.

描述（由申请人提供）：非洲裔美国人（AA）的发病率和死亡率最高，美国所有癌症对AA癌症患者的抑郁症进行了足够的评估和治疗，对于减轻这种不平等的癌症和健康不足的负担至关重要。当前对AA癌症患者抑郁症的知识极为有限。现有的一些研究表明，对该人群抑郁程度的认识不足。目前，尽管越来越多的证据表明非洲裔美国人的抑郁措施抑郁措施不敏感，但目前尚未验证筛查AA癌症患者抑郁症的验证。必须为AA癌症患者的抑郁症开发一种具有文化敏感的筛查工具，以提供足够的转诊和所需的护理。该工具的发展将需要对AA抑郁经验有深入的了解。该应用是对AA癌症患者抑郁症的生活经历的首次研究。这是重要的，因为AA癌的人群的大小，需要打击癌症差异以及对AA癌患者的生活质量和长期生存的影响。使用混合设计，该研究将提供有关AA抑郁经验的基线知识，并确定AA抑郁症状是仪器构造的第一步。具体目的如下：1）在患有癌症的背景下描述AA抑郁经历的含义和结构； 2）比较抑郁症和不抑郁的AA癌患者，以识别与抑郁症有关的癌症的信念和态度； 3）确定AA抑郁症的表现，并创建症状目录，可以将其发展为具有文化敏感的筛查工具，以评估未来的研究中AA癌症患者的抑郁症。访谈样本将包括80例癌症患者-20例患者中的四组：3组和一个由两个亚组组成的白人组，因抑郁程度而异。该小组成员将根据年龄和癌症诊断进行进一步分层，以进行录音，转录和分析的非结构化个人访谈。在验证阶段，将招募另外10名AA癌症患者，以确定研究结果的信誉。使用NUDIST软件的定性数据分析将识别主题及其关系以描述：1）AA癌症患者的抑郁经验的含义和结构； 2）关于癌症的信念和态度； 3）对抑郁经历的自我解释。使用统计和定性方法的混合方法分析将用于识别AA抑郁症状。因此，将构建清单鉴定出AA抑郁症状的症状目录，以便在未来的研究中可以开发出具有文化敏感的筛查工具，以评估AA癌症患者的抑郁症。