CORE--TRANSGENICS

核心——转基因

• 批准号: 6944162
• 负责人: BRADFORD B LOWELL
• 金额: $ 15.39万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6944162
• 关键词: animal breeding; biomedical facility; diabetes mellitus; disease /disorder model; embryo /fetus preservation; endocrinology; gene targeting; genetically modified animals; genotype; laboratory mouse; mutant; obesity

The BADERC Transgenic Mouse Core is a service facility that will utilize investigator-derived DNA constructs to create founder transgenic mice and investigator-derived targeted ES cell clones to generate gene knockout mice that can be used to address questions relevant to obesity, diabetes and endocrinology research. The BADERC Transgenic Mouse Core is a cooperative member component of the existent, and highly successful, transgenic facility operating at the BIDMC. In addition to the services listed above, the Core will also perform cryopreservation of mutant mouse lines as well as rederivation, as needed. Finally, the Core will provide consultation to BADERC investigators in all aspects of transgenic and gene knockout mice.

BADERC 转基因小鼠核心是一个服务设施，将利用研究者衍生的 DNA 构建体来创建创始转基因小鼠，并利用研究者衍生的靶向 ES 细胞克隆来生成基因敲除小鼠，可用于解决与肥胖、糖尿病和内分泌学研究相关的问题。 BADERC 转基因小鼠核心是 BIDMC 现有且非常成功的转基因设施的合作成员组成部分。除了上面列出的服务外，核心还将根据需要对突变小鼠系进行冷冻保存以及再衍生。最后，核心将为BADERC研究人员提供转基因和基因敲除小鼠各方面的咨询。