Mobility Among Older African Americans and Whites

老年非裔美国人和白人的流动性

• 批准号: 7086248
• 负责人: Richard M. Allman
• 金额: $ 49.94万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7086248
• 关键词: African American; acute phase protein; aging; behavioral /social science research tag; blood chemistry; body weight; caucasian American; chordate locomotion; clinical research; functional ability; geriatrics; health behavior; high performance liquid chromatography; human subject; inflammation; interleukin 6; interview; longitudinal human study; neuropsychology; nursing homes; nutrition of aging; psychological aspect of aging; racial /ethnic difference; self care; space perception; statistics /biometry

DESCRIPTION: (provided by applicant) The hypotheses underlying the proposed research are that potentially modifiable factors predict mobility (life-space) trajectories associated with aging among community-dwelling African Americans (AAs) and whites. Moreover, there are racial differences in these trajectories and in risk factors for life-space changes. The research team proposes to continue a prospective, observational study of a population-based sample of 1000 community-dwelling older adults (251 African American (AA) males, 249 AA females, 250 white males and 250 white females; 54 percent rural) for a total of 7 years of follow-up. New specific aims include: (1) Assess the predictors of life-space trajectories; (2) Identify predictors of transitions to restricted life-space, homebound status, and nursing home placement; (3) Examine proximate causes of life-space transitions; 4) Evaluate changes in hypothesized risk factors as predictors of life-space trajectories; (5) Determine the relationship of nutritional status with subsequent life-space trajectories; (6) Evaluate specific markers of inflammation as potential predictors of life-space. Repeat in-home assessments (N=780) 48-months after the baseline (1999-2001) in-home assessment will permit documentation of changes in disease and geriatric syndrome status, europsychological factors, nutritional status, health behaviors, and medication use since baseline. Fasting blood specimens (N=662) will be obtained within one month of the 48-month in-home assessment to assess nutrition-related lab tests, measures of inflammation, and other lab tests reflecting disease severity or management. Three 24-hour recall dietary intakes also will be obtained within 3 weeks of the in-home assessment. Telephone follow-up interviews every 6 months will be used to ascertain subsequent life-space. Multivariable, hierarchical mixed model growth curve analyses and generalized estimating equation (GEE) approaches will be used for analyses to permit identification of predictors of life-space trajectories and of specific life-space transitions. The results of this research will lead to interventions that will foster independence of older AAs and whites.

描述：（由申请人提供）拟议研究的假设是，潜在可改变的因素可以预测与居住在社区的非裔美国人（AA）和白人的老龄化相关的流动性（生活空间）轨迹。此外，这些轨迹和生活空间变化的风险因素存在种族差异。 研究小组提议继续对 1000 名社区老年人（251 名非裔美国人 (AA) 男性、249 名 AA 女性、250 名白人男性和 250 名白人女性；54% 是农村人）进行前瞻性观察研究，总共随访7年。新的具体目标包括：（1）评估生命空间轨迹的预测因子； (2) 确定向受限生活空间、居家状态和疗养院安置转变的预测因素； (3) 检查生活空间转变的近因； 4）评估假设的风险因素的变化，作为生命空间轨迹的预测因子； （5）确定营养状况与后续生命空间轨迹的关系； (6) 评估炎症的特定标志物作为生命空间的潜在预测因子。在基线（1999-2001）48个月后重复家庭评估（N = 780），家庭评估将允许记录疾病和老年综合症状态、欧洲心理因素、营养状况、健康行为和药物使用的变化，因为基线。将在为期 48 个月的家庭评估后的 1 个月内获取空腹血液样本 (N=662)，以评估与营养相关的实验室测试、炎症测量以及反映疾病严重程度或管理的其他实验室测试。在家评估后 3 周内还将获得 3 个 24 小时回忆饮食摄入量。每 6 个月进行一次电话随访，以确定后续的生活空间。多变量、分层混合模型生长曲线分析和广义估计方程（GEE）方法将用于分析，以识别生命空间轨迹和特定生命空间转变的预测因子。这项研究的结果将导致采取干预措施，促进老年 AA 和白人的独立性。