Ovarian Failure Among Hysterectomized Women

子宫切除女性的卵巢功能衰竭

基本信息

批准号：
7110125
负责人：
Patricia G Moorman
金额：
$ 73.91万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2008-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Early menopause may increase the risk of osteoporosis, cardiovascular disease, and all-cause mortality. For approximately 20% of the female population, age at menopause is unknown because they had a hysterectomy without bilateral oophorectomy before their menstrual periods ended. There is some evidence to suggest that hysterectomized women who retain their ovaries are likely to experience ovarian failure earlier that women who go through natural menopause, however most prior studies had important limitations, including small sample size, lack of comparison group, and imprecise measures of menopausal status. In the proposed 5-year study, we will investigate whether hysterectomized women who retain at least one ovary are more likely to experience ovarian failure than women of similar age who have an intact uterus and ovaries. We will recruit 500 premenopausal women aged 30 to 47 years who are undergoing hysterectomy without bilateral oophorectomy at Duke University Medical Center or Durham Regional Hospital, and 500 non-hysterectomized, premenopausal women frequency matched on age and race from gynecology practices in the Durham, North Carolina area. At baseline, all women will have a blood sample drawn and complete an interview focusing on reproductive, hormonal, and lifestyle characteristics that may be related to ovarian function. Serum samples will be analyzed for follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol. Women will be recontacted annually to have another blood sample drawn and update questionnaire information, particularly menopausal symptoms and hormone use. Menopausal status at each follow-up will be determined for all women using an algorithm based on measurements of FSH, estradiol, and LH. The primary goals of the study are: 1) to determine whether the risk of ovarian failure during the approximate 4 years of follow-up is greater for hysterectomized women than non-hysterectomized women, and 2) to evaluate the associations between medical, reproductive, and lifestyle characteristics and early ovarian failure. Hysterectomy is the most common non-obstetrical surgery in the United States, with over 600,000 procedures performed each year. The proposed study will contribute greatly to our understanding of the long-term effects of hysterectomy on ovarian function. It should have considerable public health impact given the high frequency of the procedure and the important health consequences of early ovarian failure.

描述（由申请人提供）：更年期可能会增加骨质疏松症，心血管疾病和全因死亡率的风险。在大约20％的女性人口中，更年期的年龄尚不清楚，因为在月经期结束之前，他们进行了子宫切除术，没有双侧卵形切除术。有证据表明，保留卵巢的子宫切除妇女可能会较早遭受卵巢衰竭，即经历了自然更年期的妇女，但是大多数先前的研究都有重要的局限性，包括小样本量，缺乏比较组和绝经状况的不当措施。在拟议的5年研究中，我们将研究保留至少一个卵巢的子宫切除妇女是否比具有完整子宫和卵巢的妇女更有可能经历卵巢衰竭。 We will recruit 500 premenopausal women aged 30 to 47 years who are undergoing hysterectomy without bilateral oophorectomy at Duke University Medical Center or Durham Regional Hospital, and 500 non-hysterectomized, premenopausal women frequency matched on age and race from gynecology practices in the Durham, North Carolina area.在基线时，所有妇女都将获得抽血样本，并完成一项访谈，重点是与卵巢功能有关的生殖，荷尔蒙和生活方式特征。血清样品将分析刺激激素（FSH），黄体生成激素（LH）和雌二醇的卵泡样品。妇女每年都会重新连接以获取另一个血液样本并更新问卷的信息，尤其是更年期症状和激素的使用。每个随访的更年期状态将根据FSH，雌二醇和LH的测量算法确定所有女性。该研究的主要目标是：1）确定子宫切除妇女在大约4年的随访中卵巢衰竭的风险是否高于非遗体切除妇女，以及2）评估医学，生殖和生活方式特征与早期卵巢衰竭之间的关联。子宫切除术是美国最常见的非脑手术，每年进行60万手术。拟议的研究将有助于我们对子宫切除术对卵巢功能的长期影响的理解。鉴于该程序的高频率以及早期卵巢衰竭的重要健康后果，它应该具有很大的公共卫生影响。