Sleep/Cognitive Performance/Older Adults/Insomnia

睡眠/认知表现/老年人/失眠

基本信息

批准号：
7054786
负责人：
Christina S McCrae
金额：
$ 14.02万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-05-01 至 2008-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Insomnia affects up to 35 percent of individuals aged 65 and older. Although older adults with insomnia (OAWI) frequently complain of impaired cognitive functioning, objective evidence of such impairment has been sparse. Recently, however, a handful of correlational studies have found evidence of deficits in cognitive performance in OAWI. Unfortunately, because the typical correlational design utilizes 'one shot' assessments, these studies provide only a 'snapshot' of the sleep/cognition relationship. This approach could be improved as both sleep and cognitive performance may exhibit considerable day-to-day variability, particularly in older adults. Using repeated daily assessments, these fluctuations in sleep and cognition (intraindividual variability or IIV) can be captured and modeled. Because sleep is believed to play a role in cortical recovery, it is hypothesized that variability in sleep will predict variability in cognitive performance. In the proposed study, OAWI will complete daily diaries (sleep & cognitive) throughout the course of a standard behavioral treatment program for insomnia. This study is particularly innovative, because it will be the first to employ daily diary methodology and recent advances in IIV modeling in the context of an intervention design. This novel design/methodology combination will provide unique insights into the sleep/cognition relationship in OAWI and as a result, will make valuable contributions to the fields of sleep and cognition. The two (2) specific aims of this project and their associated subaims are: Aim 1: To confirm the effects of sleep treatment on sleep outcomes, and to explore transfer of sleep intervention to cognition. Subaim 1.1: To investigate influence of sleep treatment on pre-post changes in sleep and cognition. Subaim 1.2: To investigate changes in sleep and cognitive intraindividual variability as a consequence of insomnia treatment. Aim 2: To investigate the dynamic relationship between sleep and cognition over time. Subaim 2.1: To investigate concurrent associations between level and variability in sleep and cognition. Subaim 2.2: To investigate lagged relationships between level and variability in sleep and cognition. Subaim 2.3: To investigate whether there exist homogeneous subgroups with varying patterns of sleep-cognition relationships. This study is not a treatment efficacy study per se. Previous research has already shown behavioral treatment to be effective for late-life insomnia. The success of the proposed treatment will be evaluated, however, and comparisons in IIV in cognitive functioning and sleep between successfully treated and untreated individuals will be made (see Specific Aim 1).

描述（由申请人提供）：失眠影响65岁及以上的人中有35％。尽管失眠（OAWI）的老年人经常抱怨认知功能受损，但这种障碍的客观证据却很少。然而，最近，少数相关研究发现了Oawi认知表现不足的证据。不幸的是，由于典型的相关设计利用了“一击”评估，因此这些研究仅提供了睡眠/认知关系的“快照”。这种方法可以改善，因为睡眠和认知表现都可能表现出可观的日常变异性，尤其是在老年人中。使用重复的每日评估，可以捕获和建模这些睡眠和认知（内部变异性或IIV）中的这些波动。由于据信睡眠在皮质恢复中起作用，因此假设睡眠的变异性可以预测认知能力的变异性。在拟议的研究中，OAWI将在整个标准的失眠计划过程中完成每日日记（睡眠和认知）。这项研究特别是创新的，因为它将在干预设计的背景下首次采用日记方法和IIV建模的最新进展。这种新颖的设计/方法组合将为Oawi的睡眠/认知关系提供独特的见解，结果将为睡眠和认知领域做出宝贵的贡献。该项目及其相关的两个（2）具体目标是：目标1：确认睡眠治疗对睡眠结果的影响，并探索睡眠干预转移到认知。 Subaim 1.1：研究睡眠治疗对睡眠和认知前验证前变化的影响。 Subaim 1.2：研究由于失眠治疗而导致睡眠和认知内部变异性的变化。目标2：随着时间的流逝，研究睡眠与认知之间的动态关系。 Subaim 2.1：研究睡眠和认知级别与变异性之间的并发关联。 Subaim 2.2：研究睡眠和认知水平与变异性之间的滞后关系。 Subaim 2.3：研究是否存在具有不同睡眠认知关系模式的同质亚组。这项研究本身不是治疗功效研究。先前的研究已经表明行为治疗对晚年失眠有效。但是，将评估所提出的治疗的成功，并将在成功治疗和未经治疗的个体之间进行认知功能和睡眠的IIV比较（请参阅特定目标1）。