HR-QOL in Colorectal Cancer Survivors with Stomas

有造口的结直肠癌幸存者的 HR-QOL

• 批准号: 6764939
• 负责人: Robert Scott Krouse
• 金额: $ 41.34万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6764939
• 关键词: age difference; behavioral /social science research tag; clinical research; colon surgery; colorectal neoplasms; comorbidity; coping; focus groups; functional ability; gender difference; health surveys; human subject; information dissemination; jejunectomy /duodenectomy /ileectomy; long term survivor; mental health; quality of life; racial /ethnic difference; religion; social adjustment

DESCRIPTION (provided by applicant): The purpose of this multi-method cross-sectional study is to identify health-related Quality of Life (HR-QOL) concerns specific to long-term colorectal cancer survivors (> 5 years from diagnosis) with intestinal stomas and relate those concerns to underlying disease state, time with stoma, comorbidities, as well as other demographic characteristics such as age, gender, and ethnicity. In addition, the skills and methods of adaptation to ostomies, as well as persisting challenges will be explored to gather insights about potential interventions that may be useful to improving HR-QOL for these patients. Long-term objectives are to generate targeted innovative psychosocial interventions designed to facilitate adaptation to stomal challenges and factors impinging on HR-QOL in long-term colorectal cancer survivors with stomas. Based on study results, a program of research will be developed to test interventions. Study methods will include collection of HR-QOL data using well-validated instruments in a mailed survey of long-term (> 5 years after diagnosis) colorectal cancer survivors with and without ostomies who are in care in two large, multiethnic Kaiser Permanente regions. Following completion of the survey, focus groups will be held, separate for men and women, to investigate the coping skills and barriers for those in the highest and lowest quartiles of HR-QOL. The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings.

描述（由申请人提供）： 这项多方法横断面研究的目的是确定患有肠造口的长期结直肠癌幸存者（诊断后 5 年以上）特有的与健康相关的生活质量 (HR-QOL) 问题，并将这些问题与潜在的问题联系起来。疾病状态、造口时间、合并症以及其他人口特征，如年龄、性别和种族。此外，还将探讨适应造口术的技能和方法以及持续存在的挑战，以收集有关可能有助于改善这些患者的 HR-QOL 的潜在干预措施的见解。长期目标是制定有针对性的创新心理社会干预措施，旨在促进有造口的长期结直肠癌幸存者适应造口挑战和影响 HR-QOL 的因素。根据研究结果，将制定一项研究计划来测试干预措施。研究方法将包括使用经过充分验证的仪器对在两个大型多民族 Kaiser Permanente 地区接受护理的长期（诊断后 5 年以上）结直肠癌幸存者进行邮寄调查，收集 HR-QOL 数据，这些幸存者有或没有造口。调查完成后，将分别针对男性和女性举行焦点小组会议，以调查 HR-QOL 最高和最低四分位数的人的应对技能和障碍。最后一步是召集提供者研究人员根据研究结果对未来的干预措施和传播方法提出建议。