ACTIVITY 1: MOLECULAR NEUROBIOLOGY UNIT

活动 1：分子神经生物学单元

• 批准号: 7336038
• 负责人: CONCHITA ZUAZAGA
• 金额: $ 8.89万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336038
• 关键词: gene expression; neurobiology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this proposal was to expand the capability of investigators at the Institute of Neurobiology for carrying out research on the regulation of gene expression in neurobiological systems. The thrust of this expansion was to develop a molecular neurobiology unit at the Institute. Specifically, the aims of this proposal were to : 1) obtain the equipment required for carrying out this kind of research, and 2) provide salary support for one senior postdoctoral level investigator. The requested euipment and personnel were used to expand the following on-going projects by resident scientists: 1) molecular mechanisms that underlie A-current diversity in a lobster motor system, 2) molecular determinants of protein kinase A modulation of heart sodium channels, 3) role of engrailed paralogues in specification of neuronal anatomy and synaptic connections, 4) the crayfish myomodulin neuropeptides: precursor organization and gene expression, 5) amine receptor gene expression and status in the dominance hierarchies of a tropical prawn, and 6) changes in gene expression induced by basic fibroblast growth factor after optic nerve injury. The addition of a molecular neurobiology unit to study the structure, function or expression of specific neural proteins would significantly enhance the overall research capacity and opportunities for scientific training at the Institute. Although these studies are basic in nature, they addressed important molecular mechanisms that are critical for understanding neurological conditions affecting the Puerto Rican population

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。该提案的长期目标是扩大神经生物学研究所研究人员开展神经生物学系统基因表达调控研究的能力。这次扩张的目的是在研究所建立一个分子神经生物学单位。具体来说，该提案的目的是：1）获得开展此类研究所需的设备，2）为一名高级博士后级别研究人员提供薪资支持。所要求的设备和人员被常驻科学家用于扩展以下正在进行的项目：1) 龙虾运动系统中 A 电流多样性的分子机制，2) 蛋白激酶 A 调节心脏钠通道的分子决定因素，3 ) 内嵌旁系同源物在神经元解剖学和突触连接规范中的作用，4) 小龙虾肌调节蛋白神经肽：前体组织和基因表达，5) 胺受体基因热带虾的优势等级的表达和状态，以及 6) 视神经损伤后碱性成纤维细胞生长因子诱导的基因表达的变化。增加分子神经生物学单位来研究特定神经蛋白的结构、功能或表达将显着增强该研究所的整体研究能力和科学培训机会。尽管这些研究本质上是基础性的，但它们解决了重要的分子机制，对于了解影响波多黎各人口的神经系统疾病至关重要