Diffuse optical brain imaging for stroke rehabilitation

弥散光学脑成像用于中风康复

• 批准号: 6773273
• 负责人: GARY E STRANGMAN
• 金额: $ 14.61万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6773273
• 关键词: bioimaging /biomedical imaging; biotechnology; brain circulation; brain disorder diagnosis; brain imaging /visualization /scanning; brain mapping; clinical research; data collection methodology /evaluation; diagnosis design /evaluation; diagnosis quality /standard; functional magnetic resonance imaging; human subject; learning disorders; neural plasticity; noninvasive diagnosis; patient oriented research; rehabilitation; sensorimotor system; stroke; stroke therapy

DESCRIPTION (provided by applicant): The candidate's primary interest is to understand the reorganization and recruitment associated with sensorimotor learning in healthy and stroke populations. The proposed research will test two primary hypotheses: 1) that a relatively new brain imaging technique, diffuse optical tomography (DOT), is able to detect and map learning-related modulations in brain function, and 2) that learning-related modulations in primary and secondary motor cortices are larger - both spatially and in amplitude - and less lateralized in hemiparetic stroke patients than the changes in these regions in control subjects. To test these hypotheses, the research project will first characterize and validate the DOT technique by employing simultaneous DOT and functional magnetic resonance imaging (fMRI) as both healthy and patient volunteers perform motor tasks. The fMRI activation maps will serve as a spatial "gold standard" to which the simultaneously acquired optical imaging maps will be co-registered and compared. Comparisons will be performed within and between populations, with data analysis enhanced by models of the physiological noise in the DOT recordings as well as tuning of DOT image reconstruction algorithms. We expect this approach to provide a validated technique for detecting hemodynamic changes in the brain with the advantages of portability, unobtrusiveness, low cost, and spectroscopic information. The final component of the research plan will be a pilot application of DOT brain imaging during a gait re-acquisition task. This DOT application will be performed in a rehabilitation setting, infeasible for other brain imaging methods. In conjunction with the proposed research plan, the candidate seeks training in one primary and one secondary area. The primary area of training will be in stroke: The etiology and consequences thereof, associated rehabilitation, as well as general patient-focused research methods. The secondary area will cover cutting-edge DOT image reconstruction and data analysis techniques. Completion of this training will allow the candidate to pursue an independent research program in basic and clinical neuroscience addressing questions related to functional brain reorganization in healthy and patient populations. Importantly, use of the DOT technology in such a research program is expected to enable the investigation of tasks and populations that are otherwise beyond the reach of existing brain imaging technologies.

描述（由申请人提供）：候选人的主要兴趣是了解健康和中风人群中与感觉运动学习相关的重组和招募。拟议的研究将测试两个主要假设：1）一种相对较新的大脑成像技术，即扩散光学断层扫描（DOT），能够检测和绘制大脑功能中与学习相关的调节，2）初级大脑中与学习相关的调节与对照受试者相比，偏瘫中风患者的次级运动皮层在空间和幅度上都更大，并且侧化程度更小。为了测试这些假设，该研究项目将首先在健康志愿者和患者志愿者执行运动任务时采用同步 DOT 和功能磁共振成像 (fMRI) 来表征和验证 DOT 技术。功能磁共振成像激活图将作为空间“黄金标准”，同时采集的光学成像图将与其进行共同配准和比较。将在群体内部和群体之间进行比较，通过 DOT 记录中的生理噪声模型以及 DOT 图像重建算法的调整来增强数据分析。我们期望这种方法能够提供一种经过验证的技术，用于检测大脑中的血流动力学变化，并具有便携、不引人注目、低成本和光谱信息等优点。该研究计划的最后一部分将是在步态重新获取任务中试点应用 DOT 脑成像。该 DOT 应用将在康复环境中进行，这对于其他脑成像方法来说是不可行的。结合拟议的研究计划，候选人寻求一个主要领域和一个次要领域的培训。培训的主要领域是中风：病因及其后果、相关康复以及以患者为中心的一般研究方法。次要领域将涵盖尖端的 DOT 图像重建和数据分析技术。完成本次培训将使候选人能够从事基础和临床神经科学的独立研究项目，解决与健康和患者群体的功能性大脑重组相关的问题。重要的是，在此类研究计划中使用 DOT 技术预计将能够对现有脑成像技术无法完成的任务和人群进行调查。