Minority Pre Doctoral Fellowship Program

少数族裔博士前奖学金计划

• 批准号: 7097331
• 负责人: CERRONE R FOSTER
• 金额: $ 2.87万
• 依托单位: EAST TENNESSEE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-06 至 2007-07-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7097331
• 关键词: RNA biosynthesis; aminoglycoside antibiotics; antiinfective agents; conformation; genetic transcription; genetic translation; inhibitor /antagonist; neomycin; predoctoral investigator; protein biosynthesis; ribosomal RNA; ribosomes

DESCRIPTION (provided by applicant): This work is intended to explore the observation that many antibiotics which inhibit the translational functions of the bacterial ribosome also prevent its assembly in microbial cells. These antibiotics interact with sequences in the ribosomal RNA in the ribosomal subunits. Studies will be conducted to look at the direct binding of different antibiotics to ribosomal RNA and to subunit precursors in order to explore the mechanism of assembly inhibition. Inhibitory effects of the drugs on the conformational changes in rRNA needed for particle synthesis will also be explored. This work will help define the features of the ribosome structure as a target for antimicrobial agents and will provide information needed for the design of more effective antibiotics.

描述（由申请人提供）：这项工作旨在探索许多抑制细菌核糖体翻译功能的抗生素也阻止其在微生物细胞中组装的观察结果。这些抗生素与核糖体亚基中的核糖体 RNA 序列相互作用。将进行研究观察不同抗生素与核糖体RNA和亚基前体的直接结合，以探索组装抑制机制。还将探讨药物对颗粒合成所需的 rRNA 构象变化的抑制作用。这项工作将有助于定义作为抗菌药物靶标的核糖体结构的特征，并将为设计更有效的抗生素提供所需的信息。