The molecular basis of olfaction in Drosophila larvae

果蝇幼虫嗅觉的分子基础

• 批准号: 7113764
• 负责人: Scott A KREHER
• 金额: $ 0.98万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113764
• 关键词: Drosophilidae; chemoreceptors; genetically modified animals; larva; molecular genetics; neurogenetics; neurophysiology; olfactions; predoctoral investigator

DESCRIPTION (provided by applicant): Animals use their olfactory sensory systems to interact with the complex and heterogeneous environment. Although we have discovered much about how olfactory systems work, we still do not well understand how an odor is translated into information in the brain. The Drosophila larva is an ideal system in which to test hypotheses about odor coding. Larvae have few olfactory receptor neurons, yet display sophisticated olfactory mediated behaviors. I propose an examination of olfactory receptors in Drosophila larvae using genetic, behavioral, and physiological analysis. I will test the hypothesis that Odorant receptor (Or) genes act as olfactory receptors in the larva. Furthermore, I plan to test the contribution of Or genes to olfactory behavior in the larvae.

描述（由申请人提供）：动物利用嗅觉系统与复杂且异质的环境相互作用。尽管我们已经对嗅觉系统的工作原理有了很多了解，但我们仍然不太了解气味是如何在大脑中转化为信息的。果蝇幼虫是测试气味编码假设的理想系统。幼虫几乎没有嗅觉受体神经元，但表现出复杂的嗅觉介导的行为。我建议使用遗传、行为和生理分析来检查果蝇幼虫的嗅觉受体。我将检验气味受体 (Or) 基因在幼虫中充当嗅觉受体的假设。此外，我计划测试 Or 基因​​对幼虫嗅觉行为的贡献。