Fast iZQC for High Resolution MRS In Vivo

快速 iZQC 用于高分辨率体内 MRS

• 批准号: 7125955
• 负责人: GIGI GALIANA
• 金额: $ 4.42万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-19 至 2008-09-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125955
• 关键词: athymic mouse; bioimaging /biomedical imaging; image enhancement; laboratory mouse; magnetic resonance imaging; predoctoral investigator; technology /technique development

DESCRIPTION (provided by applicant): This proposal describes a method to acquire high resolution magnetic resonance spectra from previously inaccessible organs. In most organs, inhomogeneity makes the assignment of peaks to chemical components difficult and spurious, but intermolecular zero quantum coherences (iZQCs) are insensitive to inhomogeneity. iZQCs are unique in that they give very high resolution spectra in inhomogenous samples, such as human tissue. Resolution enhancement in vivo, however, has proven elusive. Our results indicate that this is due to physiological fluctuations during the relatively slow acquisition of the iZQC signal. This has motivated us to develop a new fast acquisition method for iZQCs which will allow us to take many averages to mute the vagaries of these physiological fluctuations. We present this sequence, along with preliminary results acquired on phantoms for up to 31-fold speedup. This proposal outlines our method for progressing to still faster acquisitions and other improvements, such as water suppression, that will allow us to develop this into a robust technique in vivo.

描述（由申请人提供）：该提案描述了一种从以前无法接近的器官中获取高分辨率磁共振光谱的方法。在大多数器官中，不均匀性使化学成分峰的分配变得困难和虚假，但是分子间零量子相干（IZQC）对不均匀性不敏感。 IZQC是独一无二的，因为它们在不孔子的样品（例如人体组织）中提供了很高的分辨率光谱。但是，在体内的分辨率增强已被证明难以捉摸。我们的结果表明，这是由于IZQC信号的相对缓慢获取过程中的生理波动所致。这促使我们为IZQC开发了一种新的快速获取方法，这将使我们能够以许多平均值静音这些生理波动的变化。我们介绍了此序列，以及在幻影上获得的初步结果，以达到31倍的速度。该提案概述了我们进步的方法，以更快的收购和其他改进（例如抑制水），这将使我们能够在体内发展为强大的技术。