Neurochemical and Behavioral Alterations in Reward

奖励中的神经化学和行为改变

• 批准号: 7057187
• 负责人: NICOLE C BARBARICH-MARSTELLER
• 金额: $ 0.48万
• 依托单位: ASSOCIATED UNIV-BROOKHAVEN NATL LAB
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2006-06-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7057187
• 关键词: Neurochemical; Behavioral; Alterations; Reward

DESCRIPTION (provided by applicant): The motivation and desire to obtain a reward underlies many behaviors ranging from natural incentives such as the intake of food to the pharmacological modulation of brain circuitry involved with drugs of abuse. Substantial evidence suggests that the mesolimbic dopamine (DA) system plays a key role in modulating the neurochemical circuitry involved in reward pathways. Alterations in DA activity may underlie individual differences in reward sensitivity as well as the propensity to pursue rewarding stimuli despite undesirable consequences. Moreover, recent evidence suggests that a disturbance in one system affecting reward changes the responsiveness of other reward-related systems. Given that DA influences the properties of a reward, the goal of this proposal is to measure the specific behavioral and neurochemical changes that occur following experimental manipulation of food and drug reward pathways. First, I will use conditioned place preference to determine if food restricted rats will select an environment associated with food over an environment associated with cocaine. Second, I will use 11 C-raclopride and microPET, in combination with AMPT, to measure changes in D2 receptor number induced by chronic food restriction and/or cocaine use.

描述（由申请人提供）： 获得奖励的动机和愿望是许多行为的基础，从天然激励措施（例如食物的摄入量）到与滥用药物有关的脑电路的药理调节。大量证据表明，中脱甲贝胺（DA）系统在调节奖励途径涉及的神经化学电路中起关键作用。 DA活动的改变可能是奖励敏感性的个体差异以及尽管后果不受欢迎的倾向以及追求奖励刺激的倾向。此外，最近的证据表明，影响奖励的一种系统的干扰会改变其他与奖励相关系统的响应能力。鉴于DA会影响奖励的特性，因此该提案的目的是衡量食物和药物奖励途径实验操作后发生的特定行为和神经化学变化。首先，我将使用条件的地点偏好来确定限制食物的大鼠是否会在与可卡因相关的环境中选择与食物相关的环境。其次，我将使用11个C-丙二醇和MicroPET与AMPT结合使用，以测量慢性食品限制和/或可卡因使用引起的D2受体数量的变化。