A Transdisciplinary Approach to Cannabis Addiction

大麻成瘾的跨学科方法

• 批准号: 7223240
• 负责人: JOSEPH P. SCHACHT
• 金额: $ 3.04万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-29 至 2009-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7223240
• 关键词: Cannabis; clinical research

DESCRIPTION (provided by applicant): This application proposes an investigation of a putative endophenotype and candidate genetic variant for cannabis abuse and dependence. A growing body of literature suggests that psychological reactions to the acute effects of marijuana may differ between frequent and infrequent cannabis users. The purpose of the proposed study is to build upon this body of research by investigating the relationship between frequency of marijuana use and subjective reactions to the acute effects of marijuana. A promising candidate genetic locus, the CNR1 SNP, rs2023239, will also be examined, with respect to its relationship to the endophenotype of differential subjective reaction and to its functional significance. Frequent and infrequent cannabis users will be recruited to examine: 1) whether a significant between-group difference in psychological reaction to an acute marijuana administration episode exists, such that frequent users report more positive and fewer negative psychological reactions; 2) whether the effect of the SNP on subjective reaction mediates its effect on frequency of cannabis use; and 3) what the functional significance of the CNR1 SNP is with respect to the function of the cannabinoid receptor gene. Findings will contribute to the development of an endophenotype of cannabis use-related psychopathology. As discussed in the application, problem use of marijuana presents a growing public health problem. Marijuana is the most commonly used illicit drug in the United States and most of the world, and a growing percentage of users now report difficulties in controlling their marijuana use. The proposed research will aid treatment of problem marijuana use by attempting to identify genetic and behavioral markers that make people more likely to develop cannabis abuse or dependence. Knowledge of these markers will allow health care providers to create targeted interventions to treat these disorders.

描述（由申请人提供）：本申请提出了针对大麻滥用和依赖性的推定内表型和候选遗传变异的研究。越来越多的文献表明，对大麻的急性影响的心理反应在频繁和不经常的大麻使用者之间可能有所不同。拟议的研究的目的是通过研究大麻使用频率与主观反应与大麻急性影响之间的关系来建立这项研究体系。也将研究一个有前途的候选遗传基因座CNR1 SNP RS2023239，就其与差异主观反应的内形型及其功能意义的关系而言。将招募频繁和不频繁的大麻使用者来检查：1）是否存在对急性大麻给药事件的心理反应的显着差异，使得频繁的使用者报告的更积极和更少的负面心理反应； 2）SNP对主观反应的影响是否介导了其对大麻使用频率的影响； 3）CNR1 SNP的功能意义与大麻素受体基因的功能有关。发现将有助于发展与大麻使用相关的心理病理学的内形型。如应用程序中所述，大麻的问题使用提出了日益增长的公共卫生问题。大麻是美国和世界上大部分地区最常用的非法药物，现在越来越多的用户报告了控制大麻使用的困难。拟议的研究将通过试图识别遗传和行为标志物，从而帮助治疗大麻的使用，从而使人们更有可能发展大麻滥用或依赖。这些标记的知识将使医疗保健提供者能够创建有针对性的干预措施来治疗这些疾病。