Dopamine's role in pain sensivity & placebo analgesia

多巴胺在疼痛敏感性中的作用

• 批准号: 7155761
• 负责人: JOHANNA MOLLY JARCHO
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155761
• 关键词: analgesia; clinical research; dopamine; dopamine receptor; pain; placebos; role

DESCRIPTION (provided by applicant): The research presented here addresses the role of the central dopamine system in endogenous pain modulation as it pertains to sensitivity to noxious stimuli, and the capacity to engage antinociceptive resources following administration of placebo analgesic. Based on substantial data from the animal literature and converging evidence from both clinical samples and healthy human volunteers, it is proposed that D2- like dopamine receptor density in neural components of the primary dopaminergic reward pathway is differentially associated with these modulatory capacities. It is also proposed that beliefs regarding magnitude and probability of receiving a purportedly active analgesic will affect the relationship between placebo response and D2 dopamine receptor density. The proposed study will test whether baseline pain sensitivity and placebo analgesia when there is a high or low probability of receiving a purportedly active treatment are associated with D2/D3 dopamine receptor availability in striatal and extrastriatal brain regions as measured with [18F]fallypride PET.

描述（由申请人提供）：本文提出的研究探讨了中枢多巴胺系统在内源性疼痛调节中的作用，因为它涉及对有害刺激的敏感性，以及服用安慰剂镇痛药后利用抗伤害资源的能力。基于动物文献的大量数据以及来自临床样本和健康人类志愿者的综合证据，有人提出，初级多巴胺能奖赏通路的神经成分中的 D2 样多巴胺受体密度与这些调节能力存在差异相关。还提出，关于接受据称有效镇痛药的强度和概率的信念将影响安慰剂反应和 D2 多巴胺受体密度之间的关系。拟议的研究将测试当接受所谓的积极治疗的可能性高或低时，基线疼痛敏感性和安慰剂镇痛是否与纹状体和纹状体外大脑区域中 D2/D3 多巴胺受体的可用性相关（通过 [18F]fallypride PET 测量）。

项目成果

Neuroimaging placebo effects: new tools generate new questions.

神经影像安慰剂效应：新工具产生新问题。

• DOI: 10.1038/clpt.2009.126
• 发表时间: 2009
• 期刊: Clinical pharmacology and therapeutics
• 影响因子: 6.7
• 作者: Jarcho,JM;Mayer,EA;London,ED
• 通讯作者: London,ED