BUILDING THE TOOTH: BRIDGING BIOLOGY IN MATERIAL SCIENCES

构建牙齿：在材料科学中架起生物学桥梁

• 批准号: 7089324
• 负责人: Malcolm L. Snead
• 金额: $ 8.13万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-27 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7089324
• 关键词: regeneration; tissues; tooth

DESCRIPTION (provided by applicant): We have assembled an outstanding group of scientists to work on the regeneration of the tooth and its supporting tissues. This ambitious project will require novel scientific approaches and strong collaborative interactions as high performance teams among scientific disciplines that tend to work in isolation. Scientific expertise from molecular biology, computer sciences, genetics, chemistry, physics, materials sciences and engineering are required. We use the diverse skills of our scientific team to perform a SWOT analysis to identify the Strengths, Weaknesses, Opportunities and Threats to the goal of tooth regeneration. We will create a blueprint for a human tooth that includes the materials properties, gene expression profiles, matrix molecules, and signaling pathways that draws from our existing knowledge of the development and evolution of teeth. This blueprint is used to provide the design specifics for two unique, but complementary roads to engineer a replacement. A biological approach using stem- and/or genetically engineered cells, signaling molecules and nanofabricated extracellular matrix molecules to direct regeneration is envisioned. Alternatively, biomimetic inspired molecules are used with nano- and micro technology tools to create materials that replace dental tissues. The SWOT analysis will identify gaps in knowledge or technology that impede our progress and the means to obviate them. We will create a Concept Development Plan that details and prioritizes specific processes, procedures and projects to achieve tooth regeneration and outlines the organizational structure, including the environment for promoting interdisciplinary and collaborative basic and translational applied research needed for the U54 program.

描述（由申请人提供）：我们组装了一群出色的科学家，以致力于牙齿的再生及其支撑组织。这个雄心勃勃的项目将需要新颖的科学方法和强大的协作互动，因为科学学科中的高性能团队往往是孤立地工作的。需要分子生物学，计算机科学，遗传学，化学，物理，材料科学和工程学的科学专业知识。我们利用科学团队的多种技能来执行SWOT分析，以确定牙齿再生目标的优势，劣势，机会和威胁。我们将为人类牙齿创建一个蓝图，其中包括材料特性，基因表达曲线，基质分子和信号传导途径，从我们现有的牙齿发育和演变中获取的信号通路。该蓝图用于为两条独特但互补的道路提供设计替代品的设计细节。设想了使用茎和/或基因工程细胞，信号分子和纳米制作的细胞外基质分子直接再生的生物学方法。另外，将仿生启发的分子与纳米和微技术工具一起使用，以创建替代牙科组织的材料。 SWOT分析将确定阻碍我们进步的知识或技术差距，以及消除它们的手段。我们将制定一个概念开发计划，详细说明并确定特定过程，程序和项目以实现牙齿再生并概述组织结构，包括促进U54计划所需的跨学科和协作基础和翻译应用研究的环境。