Cancer Biology Training Program

癌症生物学培训计划

• 批准号: 7116273
• 负责人: A. ANGIE RIZZINO
• 金额: $ 33.48万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-22 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116273
• 关键词: Cancer; Biology; Training; Program

DESCRIPTION (provided by applicant): The Eppley Institute is an academic unit of the University of Nebraska Medical Center (UNMC) with its sole focus on basic cancer research. It is a major component of the NCI-designated UNMC Eppley Cancer Center. UNMC has one of two NCI-designated Cancer Centers in a 6 state region of the heartland and has more than 125 faculty members involved in laboratory and clinical research. As such, the Eppley Institute and the Cancer Research Training Program (CRTP) play an important regional role in training future basic and clinical scientists. We recruit from a national pool of predoctoral and postdoctoral fellows. The NCI Training Grant supports a key part of the CRTP, which currently has 26 predoctoral and 42 postdoctoral fellows in training. The CRTP faculty have a wide variety of expertise in areas important for a broad-based cancer research training program, including biochemistry, cellular and structural biology, drug delivery, genetics, immunology, organic and medicinal chemistry, pathology pharmaceutics and pharmacodynamics, pharmacology, and clinical oncology. The Eppley Institute's CRTP does not grant a doctoral degree, and all entering graduate students have a chance to rotate with CRTP faculty before they pick a thesis advisor in one of the participating departments: Biochemistry and Molecular Biology, Pathology and Microbiology, Pharmaceutical Sciences, and Pharmacology. A number of our trainees are directly involved in translational research activities, e.g., gene-targeted therapy for leukemia, role of catechol estrogens in human breast cancer, radioimmunoconjugate therapy and tumor vaccine development, development of tumor markers for gynecologic cancer. The goal of the training grant is to provide each doctoral student and postdoctoral fellow with the knowledge base, laboratory skills, and problem solving abilities to become independent, innovative cancer investigators. The specific aims of the CRTP are to provide pre- and postdoctoral trainees with: (1) knowledge of the mechanisms of carcinogenesis, the epidemiology of human cancer, and the potential for cancer prevention; (2) an in-depth background in the areas of basic science (biochemistry and molecular biology, genetics, immunology, pathology, pharmaceutical sciences, pharmacology) that is necessary to study and understand the conversion of normal cells to cancer cells and to design methods of diagnosis and treatment; (3) the ability to apply this information to plan and conduct innovative research on the causes, prevention, diagnosis and treatment of cancer; and (4) an appreciation of the power of interdisciplinary research. To achieve these aims the CRTP must be able to attract highly qualified and motivated graduate students and postdoctoral fellows and provide them with high quality didactic and laboratory experiences.

描述（由申请人提供）：Eppley Institute是内布拉斯加大学医学中心（UNMC）的学术部门，其唯一关注基础癌症研究。 它是NCI指定的UNMC Eppley癌症中心的主要组成部分。 UNMC在心脏地带一个6个州区域中具有两个NCI指定的癌症中心之一，并且有125名教职员工参与实验室和临床研究。 因此，Eppley研究所和癌症研究培训计划（CRTP）在培训未来的基本和临床科学家中起着重要的区域作用。 我们从国家和博士后研究员的国家池中招募。 NCI培训补助金支持CRTP的关键部分，该培训目前在培训中有26个占主导地位和42个博士后研究员。 CRTP教师在对基于广泛的癌症研究培训计划重要的领域中具有广泛的专业知识，包括生物化学，细胞和结构生物学，药物递送，遗传学，免疫学，有机和药物化学，病理学药物，药物学以及药物学，药理学以及药理学以及药理学以及药理学以及临床肿瘤学。 Eppley Institute的CRTP没有授予博士学位，所有入学生都有机会与CRTP教师一起旋转，然后才能在参与部门之一中选择论文顾问：生物化学和分子生物学，病理学和微生物学，制药科学以及制药科学以及药学，以及药理。 我们的许多受训者直接参与转化研究活动，例如，基因靶向白血病，儿茶酚雌激素在人类乳腺癌中的作用，放射免疫共轭疗法和肿瘤疫苗的发展，妇科癌症的肿瘤标记的发展。 培训补助金的目的是为每个博士生和博士后研究员提供知识库，实验室技能和解决问题的能力，以成为独立，创新的癌症研究人员。 CRTP的具体目的是为：（1）了解癌变机制，人类癌症的流行病学以及预防癌症的潜力； （2）基础科学领域的深入背景（生物化学和分子生物学，遗传学，免疫学，病理学，药理学，药理学）是研究和理解正常细胞向癌细胞转化和设计方法所必需的诊断和治疗； （3）应用此信息来计划和进行有关癌症原因，预防，诊断和治疗的创新研究； （4）对跨学科研究的力量的欣赏。 为了实现这些目标，CRTP必须能够吸引高素质和积极进取的研究生和博士后研究员，并为他们提供高质量的教学和实验室经验。