TRAINING IN MOLECULAR PATHOGENESIS OF MICROBIAL DISEASES

微生物疾病分子发病机制培训

• 批准号: 7123574
• 负责人: Dennis Edward Ohman
• 金额: $ 14.74万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123574
• 关键词: TRAINING; MOLECULAR; PATHOGENESIS; MICROBIAL; DISEASES

DESCRIPTION (provided by applicant): The major goal of this continuing training program is to provide graduate students and postdoctoral fellows with a first-rate training experience in preparation for careers as competitive, independent investigators in scientific research, particularly at biomedical institutions. As part of this goal, we will recruit talented and motivated students and postdoctoral fellows that are dedicated to biomedical research. New scientists are needed in the area of molecular pathogenesis because future success in the prevention and treatment of new, resurgent, and antibiotic-resistant infectious agents will require a sophisticated understanding of the molecular basis of pathogenesis. The training program focuses on understanding molecular mechanisms of pathogenesis, host-microbe interactions, and the use of molecular biology, genomic and bioinformatic technology to study pathogenesis. This training program is directed individually by research advisors and overall by a program governance committee. Training includes rigorous laboratory research, weekly seminars, local meetings, and advanced courses. A major strength is the quality of the research programs of the 10 well-funded program faculty members from 4 departments who have productive and energetic research efforts in numerous areas of current interest. The Molecular Pathogenesis Group is highly interactive, and trainees are regularly exposed to diverse areas of research on bacteria (gonococci, obligate anaerobes, pseudomonades, spirochetes, staphylococci, streptococci), protozoan (amoebae, trypanosomes), fungal (Cryptococcus, Pneumocystis), and viral (cytomegalovirus, hepatitis, herpesvirus) pathogens using the full range of modern molecular techniques. The training program also benefits from the presence of a strong graduate program in the School of Medicine of VCU. Trainees benefit from vigorous faculty involvement, experiences in communicating their work, and excellent core facilities, all of which provide a superb environment for training the next generation of researchers in molecular pathogenesis.

描述（由申请人提供）：该持续培训计划的主要目标是为研究生和博士后研究员提供一流的培训经验，以准备作为科学研究的竞争性独立研究人员，特别是在生物医学机构的竞争性独立研究者。作为这一目标的一部分，我们将招募专门从事生物医学研究的才华横溢，积极进取的学生和博士后研究员。在分子发病机理领域需要新科学家，因为未来在预防和治疗新的，复活和抗生素耐药的传染剂方面的成功将需要对发病机理的分子基础进行复杂的理解。该培训计划的重点是理解发病机理，宿主 - 微生物相互作用的分子机制以及分子生物学，基因组和生物信息学技术的使用来研究发病机理。该培训计划由研究顾问分别由计划治理委员会指导。培训包括严格的实验室研究，每周研讨会，当地会议和高级课程。一个主要的优势是来自4个部门的10个资金资助计划的教职员工的研究计划的质量，他们在当前感兴趣的许多领域都有富有成效和充满活力的研究工作。 The Molecular Pathogenesis Group is highly interactive, and trainees are regularly exposed to diverse areas of research on bacteria (gonococci, obligate anaerobes, pseudomonades, spirochetes, staphylococci, streptococci), protozoan (amoebae, trypanosomes), fungal (Cryptococcus, Pneumocystis), and viral （巨细胞病毒，肝炎，疱疹病毒）病原体，使用各种现代分子技术。该培训计划还受益于在VCU医学院的强大研究生课程中受益。受训者受益于有力的教师参与，交流工作的经验以及出色的核心设施，所有这些都为培训下一代研究人员的分子发病机理提供了极好的环境。