Molecular Pathogenesis of Infectious Diseases

传染病的分子发病机制

• 批准号: 7081397
• 负责人: Kathryn V Holmes
• 金额: $ 8.62万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7081397
• 关键词: Molecular; Pathogenesis; Infectious; Diseases

DESCRIPTION (provided by applicant): The Molecular Pathogenesis of Infectious Diseases is an area of great interest to an interdepartmental group of 19 faculty members at the University of Colorado Health Sciences Center. This is a newly emerging area for research that encompasses molecular biological and biochemical studies on microbial virulence factors, host resistance mechanisms, regulation of gene expression during infection, structure-function analysis of microbial and host cell molecules that play key roles in infections, analysis of interactions of bacteria and viruses with differentiated host cells in vitro, and studies on infections with genetically modified bacteria and viruses in genetically modified animal models. Our faculty group has a proven record of innovative research in this area. The faculty are training 21 predoctoral students in the multidisciplinary approaches needed to understand and eventually control infectious diseases. Predoctoral students to be supported by the Molecular Pathogenesis of Infectious Diseases Graduate Student Training Grant will learn to identify and solve important research problems in medical microbiology, molecular structure, cellular interactions with bacteria and viruses, and in vivo analysis of bacterial and viral diseases. Highly qualified predoctoral students at the University of Colorado School of Medicine who are doing research on the molecular pathogenesis of bacterial or viral diseases with NIH-funded mentors on the training grant faculty will be selected for appointment to the training grant after they have completed all of their required courses, passed their preliminary and comprehensive examinations, and begun their dissertation research. We request 4 predoctoral student positions for the first year of the grant, 5 for the second year, and 6 for each successive year. Each selected student will be supported by the training grant for a minimum of 2 years during the period of dissertation research. A comprehensive program of seminars, journal clubs, and research-in-progress meetings will train the students to identify important research questions, design well-controlled experiments using a wide variety of molecular, cellular and in vivo techniques, and critically evaluate and present the results. Training in scientific communication skills and ethics in research are important components of the program. The breadth of this integrated, interdepartmental training program will prepare the students well for careers in innovative research and teaching in academia or biotechnology in the important area of the pathogenesis of infectious diseases.

描述（由申请人提供）：科罗拉多大学健康科学中心的19位教职员工组成的部门间组成的分子发病机理是一个非常有趣的领域。这是一个新兴的研究领域，用于研究有关微生物毒力因子的分子生物学和生物化学研究，宿主抵抗机制，感染过程中基因表达的调节，对微生物和宿主在感染中起着关键作用的微生物和宿主相互作用的分析，对细菌的相互作用的分析，对细菌的相互作用的结构分析，并在宿主中发挥关键作用。在转基因动物模型中。我们的教职小组在该领域拥有创新研究的可靠记录。该教师正在培训21名在理解和最终控制传染病所需的多学科方法中的21名学生。受传染性疾病的分子发病机制支持的研究生培训授权将学会识别和解决医学微生物学，分子结构，与细菌和病毒的细胞相互作用以及细菌和病毒疾病的体内分析中的重要研究问题。科罗拉多大学医学院的高素质前学生，他们正在对NIH资助的培训赠款教师的细菌或病毒疾病分子发病机理进行研究，以在完成所有必要的课程后，通过培训补助金的培训赠款，并通过了他们的所有必要的课程，并通过了他们的所有预选和全面的考试，并进行了全面的考试。我们要求赠款第一年的4个学生职位，第二年为5个，每个连续一年为6个。在论文研究期间，每个选定的学生将得到至少2年的培训资助。一项针对研讨会，期刊俱乐部和进行研究的会议的综合计划将培训学生，以确定重要的研究问题，使用各种分子，细胞和体内技术设计良好的控制实验，并进行严格的评估和呈现结果。研究研究中的科学沟通技巧和道德培训是该计划的重要组成部分。这项综合的部门间培训计划的广度将使学生为学生在学术界或生物技术的创新研究和教学职业做好准备，而在传染病的重要领域中。