Nutrition and Physical Activity Assessment Study (NPAAS)

营养和身体活动评估研究（NPAAS）

• 批准号: 7149737
• 负责人: Ross L Prentice
• 金额: $ 90.53万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-12 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7149737
• 关键词: bioenergetics; biomarker; clinical research; disease /disorder proneness /risk; food; measurement; nutrition; potassium; proteins; questionnaires; sodium

DESCRIPTION (provided by applicant): This proposal requests support for a Nutrition and Physical Activity Assessment Study within the Observational Study (OS) component of the Women's Health Initiative (WHI). The OS cohort is comprised of 93,676 postmenopausal women in the age range 50-79 when enrolled at the 40 WHI Clinical Centers in the U.S. between 1994 -1998. The study will be conducted among 450 postmenopausal weight-stable women with oversampling of racial/ethnic minority women and of women in the extremes of body mass index. Participating women will complete the same food frequency questionnaire (FFQ) and physical activity questionnaire used at screening for WHI enrollment, a four-day food record (4DFR) as was used at baseline in the WHI Dietary Modification Trial (48,835 women), and other selected dietary and physical activity assessments (three 24-hour dietary recalls, a physical activity frequency questionnaire, social desirability measures, and a 7-day physical activity recall). Participating women will follow a doubly-labeled water protocol to objectively assess total energy expenditure and an indirect calorimetry protocol to assess resting energy expenditure, thereby also yielding an objective assessment of activity-related energy expenditure. The expenditure of protein, sodium, and potassium will also be assessed from urine specimens, and the concentrations of selected nutrients will be measured in blood specimens. These data will be used to evaluate and contrast measurement properties of the dietary and physical activity assessment tools and their combination, with an emphasis on: systematic bias as a function of body mass, ethnicity, age, and other individual characteristics; the magnitude of person- specific and random measurement error variances; and the correlation patterns among errors from differing assessment procedures. Additionally, the data will be used to calibrate the FFQ, 4DFR, and physical activity questionnaire data collected at baseline, and subsequently, in the WHI, for use in a range of analyses to associate dietary and physical activity patterns with weight change and disease risk over an average 10-year follow-up period among 161,808 women in the WHI Clinical Trial and Observational Study. The study will provide much needed data regarding dietary and physical activity assessment in an understudied segment of the U.S. population, and will provide crucial information for interpreting existing studies and for future study planning.

描述（由申请人提供）：该提案要求在妇女健康计划（WHI）的观察性研究（OS）组成部分中支持营养和体育活动评估研究。 OS队列由年龄范围50-79岁的93,676名绝经后妇女组成，当时在1994年至1998年之间在美国40个WHI临床中心招收。这项研究将在450名绝经后体重稳定的妇女中进行，对种族/族裔少数民族妇女和体重指数极端的妇女进行过度采样。参与的妇女将完成与入学筛查时使用的相同食品频率问卷和体育活动问卷，在饮食修改试验中使用的为期四天的食物记录（4DFR）（48,835名女性）（48,835名女性）（48,835名女性），以及其他选择的饮食和身体活动评估（三个24小时的饮食和饮食饮食活动）（三个24小时的饮食习惯，以期为人的身体活动频率调查，一个身体活动频率和社交频率，一个人，一个社交频率，一个社交频率，一个人），一个人，一个人，一个人，一个人，一个人，一个人），一项社交频率，一个人，一个饮食和饮食活动。参与的妇女将遵循双标记的水协议，以客观地评估总能量消耗和间接的量热法，以评估静息能量消耗，从而对活动相关的能量消耗进行客观评估。蛋白质，钠和钾的支出也将从尿液标本中进行评估，并且将在血样中测量所选营养素的浓度。这些数据将用于评估和对比的饮食和体育活动评估工具的测量特性及其组合，重点是：系统偏见是体重，种族，年龄和其他个人特征的函数；人特异性和随机测量误差方差的大小；以及不同评估程序中错误之间的相关模式。此外，这些数据将用于校准基线时收集的FFQ，4DFR和体育活动问卷调查数据数据，然后在WHI中收集的数据，以在一系列分析中使用，以在161,808名妇女的平均10年随访中，将饮食和身体活动变化与体重变化和疾病的风险联系起来，并在Whi Clunical Clunical Clunical Terical Partical Partical Partical Partical Partical Partical Partical Partical Partical Partical Perigation Leation中使用。该研究将在美国人群的研究中提供有关饮食和体育活动评估的急需数据，并将为解释现有研究和未来的研究计划提供关键信息。