Heritability of Impulsivity during the Go/NoGo Task

Go/NoGo 任务期间冲动的遗传性

• 批准号: 7039130
• 负责人: Serena Bezdjian
• 金额: $ 4.38万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-14 至 2008-02-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7039130
• 关键词: antisocial personality; behavior test; behavioral /social science research tag; behavioral genetics; brain electrical activity; child behavior disorders; child psychology; clinical research; cognition; data collection methodology /evaluation; disease /disorder etiology; evoked potentials; family genetics; gene environment interaction; human subject; impulsive behavior; mental health epidemiology; middle childhood (6-11); performance; predoctoral investigator; psychomotor reaction time; psychophysiology; twin /multiplet

DESCRIPTION (provided by applicant): The proposed study aims to gain a better understanding of the etiology of impulsivity and its relationship to antisocial behavior in children within the context of an extensive behavioral, cognitive, and psychophysiological assessment battery. The study will expand on previous findings by also investigating the genetics of impulsivity during a laboratory paradigm, the Go/NoGo task. Performance measures of response latency (reaction times) and number of errors will be obtained and calculated during the task. An existing hypothesis states that faster reaction times and shorter latencies are indicative of impulsive responding. Subjects will include 600 pairs of 9 and 10-year old twins and their primary caregivers recruited from the Los Angeles county school districts. The study will be conducted in a genetically informative twin design, which will allow for the investigation of the genetic and environmental influences of impulsivity. Multivariate genetic analyses will also be employed to examine possible genetic and environmental influences of motor and behavioral impulsivity during the Go/NoGo task.

描述（由申请人提供）：拟议的研究旨在在广泛的行为，认知和心理生理评估电池中更好地了解冲动性的病因及其与儿童反社会行为的关系。这项研究将通过研究实验室范式（GO/NOGO任务）期间的冲动性遗传学来扩展以前的发现。在任务期间，将获得和计算响应潜伏期（反应时间）的性能度量（反应时间）和误差数量。现有的假设指出，更快的反应时间和较短的延迟表明冲动反应。受试者将包括从洛杉矶县学区招募的600对9和10岁的双胞胎及其主要护理人员。该研究将以遗传信息丰富的双胞胎设计进行，这将允许研究冲动性的遗传和环境影响。还将采用多元遗传分析来检查运动/NOGO任务期间运动和行为冲动的可能的遗传和环境影响。