Epidemiology of Neurocysticercosis

神经囊尾蚴病的流行病学

• 批准号: 7122945
• 负责人: ELIZABETH A KELVIN
• 金额: $ 2.65万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7122945
• 关键词: Cestoda; age difference; clinical research; family genetics; gender difference; host organism interaction; human data; larva; nervous system disorder diagnosis; nervous system disorder epidemiology; nervous system disorder therapy; nervous system infection; parasite infection mechanism; predoctoral investigator; sign /symptom; statistics /biometry

DESCRIPTION (provided by applicant): The research proposed will investigate the diverse clinical manifestations of neurocysticercosis (NCC) infection. The data that will be used was collected for a clinical trial of treatment for NCC infection that was conducted in Ecuador. Through secondary analysis, we will investigate if host factors, specifically sex, age and familial aggregation, and characteristics of the parasitic infection, specifically location in the brain and phase of evolution of the parasite, influences the clinical manifestations of NCC. Further this proposed research will investigate if the effect of host factors on the clinical symptoms of NCC infection is mediated through the characteristics of the parasitic infection. Through a better understanding of the mechanisms through which NCC causes symptoms we hope to improve diagnosis and treatment of patients afflicted with this disease and to suggest directions for future research.

描述（由申请人提供）：拟议的研究将研究神经囊肿（NCC）感染的多种临床表现。将收集将使用的数据进行用于在厄瓜多尔进行的NCC感染治疗的临床试验。通过二级分析，我们将研究宿主因素，特别是性别，年龄和家族聚集以及寄生虫感染的特征，特别是在大脑中的位置和寄生虫的进化阶段，都会影响NCC的临床表现。此外，这项拟议的研究将研究宿主因素对NCC感染的临床症状的影响是否通过寄生虫感染的特征介导。通过更好地理解NCC引起症状的机制，我们希望改善患有这种疾病的患者的诊断和治疗，并提出未来研究的方向。

项目成果

A longitudinal analysis of albendazole treatment effect on neurocysticercosis cyst evolution using multistate models.

使用多状态模型纵向分析阿苯达唑治疗对神经囊尾蚴病囊肿进化的影响。

• DOI: 10.1093/trstmh/trz073
• 发表时间: 2019
• 期刊: Transactions of the Royal Society of Tropical Medicine and Hygiene
• 影响因子: 2.2
• 作者: Montgomery,MichelleA;Ramos,Marcel;Kelvin,ElizabethA;Carpio,Arturo;Jaramillo,Alexander;Hauser,WAllen;Zhang,Hongbin
• 通讯作者: Zhang,Hongbin

The effect of albendazole treatment on non-seizure outcomes in patients with symptomatic neurocysticercosis.

阿苯达唑治疗对有症状的神经囊尾蚴病患者非癫痫发作结果的影响。

• DOI: 10.1093/trstmh/try023
• 发表时间: 2018
• 期刊: Transactions of the Royal Society of Tropical Medicine and Hygiene
• 影响因子: 2.2
• 作者: Thapa,Kriti;Romo,MatthewL;Carpio,Arturo;Leslie,Denise;Andrews,Howard;Hauser,WAllen;Kelvin,ElizabethA
• 通讯作者: Kelvin,ElizabethA