Early auditory deficits in schizophrenia

精神分裂症的早期听觉缺陷

• 批准号: 7157128
• 负责人: VICTORIA M LEAVITT
• 金额: $ 3.46万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-17 至 2009-07-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157128
• 关键词: auditory discrimination; behavioral /social science research tag; brain electrical activity; cognition disorders; disease /disorder onset; electrophysiology; evoked potentials; human middle age (35-64); human subject; neural information processing; neuropathology; neuropsychological tests; predoctoral investigator; psychopathology; schizophrenia; sound perception; young adult human (21-34)

DESCRIPTION (provided by applicant): Cognitive dysfunction is a hallmark of schizophrenia. However, underlying deficits in basic sensory processing are a contributing factor to higher order processing deficits. In the auditory system, there is evidence for functionally distinct ventral and dorsal pathways, governing sound object recognition ('what') and sound localization ('where'), respectively. The event-related potential known as mismatch negativity (MMN) has been used to index sound object recognition. It is robustly elicited in healthy subjects when a deviant tone is interjected in a train of standard tones. In schizophrenia, the MMN is significantly attenuated, providing strong evidence for deficits in early auditory processing, namely, 'what' pathway impairment. To this author's knowledge, no research has yet shown deficits in both the 'what' and 'where' pathways in schizophrenia. In the proposed study, integrity of the ventral and dorsal pathways in schizophrenia patients will be assessed through behavioral and electrophysiological tasks. For the dorsal, or 'where' pathway, a sound localization experiment will be conducted. For the ventral, or 'what' pathway, we will conduct a sound object recognition experiment. As our understanding of the specific nature of auditory system deficits in schizophrenia increases, so will avenues for diagnosis, treatment, and etiological understanding of the illness.

描述（由申请人提供）：认知功能障碍是精神分裂症的标志。但是，基本感觉处理中的潜在缺陷是导致高阶处理缺陷的一个因素。在听觉系统中，有证据表明功能上不同的腹侧和背途径，分别是声音对象识别（'What'）和声音定位（'White where'）的证据。事件相关的潜在称为不匹配负性（MMN）已用于索引声音对象识别。当将异常音调插入标准音调时，它在健康受试者中得到了强有力的引起。在精神分裂症中，MMN大大减弱，为早期听觉处理中的缺陷提供了有力的证据，即“什么”途径障碍。据该作者的知识，尚无研究表明精神分裂症的“什么”和“哪里”途径差。在拟议的研究中，精神分裂症患者的腹侧和背途径的完整性将通过行为和电生理任务进行评估。对于背侧或“在哪里”途径，将进行声音定位实验。对于腹侧或“什么”途径，我们将进行声音对象识别实验。随着我们对精神分裂症中听觉系统缺陷的特定性质的理解，诊断，治疗和病因理解的途径也会增加。