A General Synthetic Route to Glycosidase Inhibitors

糖苷酶抑制剂的通用合成路线

• 批准号: 7097157
• 负责人: AARON APONICK
• 金额: $ 3.26万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-11-16 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7097157
• 关键词: aminoalcohol; chemical synthesis; enzyme inhibitors; epoxides; glycosidases; nitrogen; palladium; postdoctoral investigator; stereoisomer; technology /technique development

DESCRIPTION (provided by applicant): The goal of the research outlined in this proposal is to investigate the scope of the palladium catalyzed dynamic kinetic asymmetric transformation (DYKAT) of racemic diene monoepoxides to enantiomerically pure 1,2-aminoalcohols and to apply this methodology to the synthesis of the natural products 2,5-dihydroxymethyl-3,4-dihydroxy- pyrrolidine, 1-deoxynojiromycin, swainsonine, 1-epi-alexine, and gualamycin, which are potent glycosidase inhibitors and represent four of the five general structural classes of these compounds. The reaction will be investigated by expanding the list of nitrogen nucleophiles and epoxides that can be used. In optimizing the reactions, advanced intermediates necessary for straightforward transformation into these inhibitors will be generated. Efficient enantioselective chemical syntheses by flexible routes using the proposed DYKAT methodology will provide a general synthetic strategy for the synthesis of a multitude of structurally similar alkaloids, which have been identified as potential pharmaceuticals in the therapeutic areas of cancer, diabetes, obesity, and anti-virals.

描述（由申请人提供）：本提案中概述的研究目标是研究外消旋二烯单环氧化物到对映体纯 1,2-氨基醇的钯催化动态动力学不对称转化 (DYKAT) 的范围，并将该方法应用于天然产物2,5-二羟甲基-3,4-二羟基-吡咯烷、1-脱氧野尻霉素的合成，苦马豆素、1-表-阿列辛和瓜拉霉素是有效的糖苷酶抑制剂，代表这些化合物的五种一般结构类别中的四种。将通过扩大可使用的氮亲核试剂和环氧化物的列表来研究该反应。在优化反应时，将产生直接转化为这些抑制剂所需的高级中间体。使用所提出的 DYKAT 方法通过灵活的途径进行高效的对映选择性化学合成将为合成多种结构相似的生物碱提供通用的合成策略，这些生物碱已被确定为癌症、糖尿病、肥胖症和抗衰老治疗领域的潜在药物。病毒。