Limits of Multi-Tetrode Intracortical Microstimulation

多极皮质内微刺激的局限性

• 批准号: 7124735
• 负责人: MARK J LEHMKUHLE
• 金额: $ 4.88万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124735
• 关键词: assistive device /technology; auditory cortex; auditory discrimination; auditory stimulus; behavior test; behavioral /social science research tag; brain electronic stimulator; deaf aid; deafness; electrodes; electrostimulus; laboratory rat; postdoctoral investigator; psychophysics; sound perception

DESCRIPTION (provided by applicant): It is not fully understood how spatial and temporal patterns of microstimulation of primary auditory cortex affect the quality of percept. The principle goal of this application is to use behavioral assays in rats to investigate the limits of sensory perceptions evoked by spatial patterns of intracortical microstimulation (ICMS) through multiple tetrode arrays implanted in primary auditory cortex of deafened rat. This application will determine if perceptual differences exist between monopolar and tripolar microstimulation of auditory cortex, and examine the quality of ICMS within (35 - 50 micrometers) and between (100 - 250 micrometers) tetrodes, through behavior. The use of behaviorally conditioned animals has the potential to be a strong indication of the quality of percept elicited by multi-site patterned microstimulation. The spatial limits of electrically-evoked auditory percepts determined through this application will aid in the design of future cortical neuroprosthetics. This work is of potentially great relevance in the development and design of an electrical brain-machine interface capable of stimulating auditory cortex in such a manner as to artificially evoke auditory perceptions.

描述（由申请人提供）：尚不完全了解主要听觉皮层的微刺激的空间和时间模式如何影响感知质量。该应用的主要目标是在大鼠中使用行为分析来研究通过植入了聋哑大鼠一级听觉皮层的多个四极管阵列，这是由心脏内微刺激（ICMS）的空间模式引起的。该应用将确定听觉皮层的单极和三极微刺激之间是否存在感知差异，并通过行为检查（35-50微米）和（100-250微米）四极管内ICM的质量。使用行为条件的动物的使用有可能有力地表明通过多站点图案化的微刺激引起的感知质量。通过此应用确定的电气诱发的听觉知觉的空间极限将有助于设计未来的皮质神经假想。这项工作可能与能够以人为唤起听觉感知的方式刺激听觉皮层的电气脑机界面的开发和设计具有很大的意义。