DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

开发和改善机构动物资源

• 批准号: 6900560
• 负责人: JANICE D. WAGNER
• 金额: $ 69.84万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6900560
• 关键词: Macaca fascicularis; Primates; community; germ free condition; housing; medicine; pregnancy; schools; university

DESCRIPTION (provided by applicant): The Wake Forest University School of Medicine (WFUSM) projects future growth of its research programs. To support this growth, construction of new animal housing space is already underway or planned on two of the institution's four campuses. Construction of new research space will require considerable institutional investment over the next few years. In collaboration with the Washington National Primate Research Center (WaNPRC), we propose to utilize WFUSM available breeding space to house breeding colonies from WaNPRC to produce specific pathogen free (SPF) infants to support research needs for the biomedical community. A concurrent P40 application is being submitted by WaNPRC, entitled "WaNPRC-WFUSM Macaca fascicularis SPF Breeding Colony". As there is a known shortage of NHP, these applications, if funded, would address a critical shortage of need for SPF monkey research subjects. This proposal requests funds to: 1) modify existing corrals to provide more usable group harem breeding corrals, and 2) provide equipment for better infant care. This G20 application and the P40 application from WaNPRC represent a cost-effective and uniquely qualified partnership to address a national need that is projected to continue well into the future. At WFUSM alone, these improvements will directly impact the research of 39 investigators who currently hold $12.2 million (annual direct costs) in externally funded projects, and 17 investigators who have applied for $7.4 million (annual direct costs) in pending projects. If funded, this application will provide a mechanism for WaNPRC and WFUSM to cost-effectively use existing resources, take advantage of each group's complementary expertise in nonhuman primate breeding and colony management, and be poised to help support new national initiatives and already successful research programs.

描述（由申请人提供）： 维克森林大学医学院 (WFUSM) 预测其研究项目的未来发展。为了支持这一增长，该机构四个校区中的两个校区已经开始或计划建设新的动物饲养空间。未来几年新研究空间的建设将需要大量的机构投资。我们与华盛顿国家灵长类研究中心 (WaNPRC) 合作，建议利用 WFUSM 的可用繁殖空间来安置来自 WaNPRC 的繁殖群体，以生产特定的无病原体 (SPF) 婴儿，以支持生物医学界的研究需求。 WaNPRC 正在同时提交 P40 申请，题为“WaNPRC-WFUSM Macaca fasciulousis SPF Breeding Colony”。由于已知 NHP 短缺，这些申请如果得到资助，将解决 SPF 猴子研究对象的严重短缺问题。该提案要求资金：1）改造现有畜栏，以提供更多可用的群体后宫繁殖畜栏，2）提供设备以更好地照顾婴儿。 G20 应用程序和 WaNPRC 的 P40 应用程序代表了一种具有成本效益且具有独特资格的合作伙伴关系，可以满足预计将持续到未来的国家需求。仅在 WFUSM，这些改进将直接影响 39 名研究人员的研究，他们目前在外部资助项目中持有 1220 万美元（年度直接费用），以及 17 名研究人员在待定项目中申请了 740 万美元（年度直接费用）。如果获得资助，该应用程序将为 WaNPRC 和 WFUSM 提供一种机制，以经济有效地利用现有资源，利用每个小组在非人类灵长类动物育种和群体管理方面的互补专业知识，并准备好帮助支持新的国家举措和已经成功的研究项目。