Maximum Drinks, Alcoholism and Psychopathology Risk

最大饮酒量、酗酒和精神病理学风险

基本信息

批准号：
7039343
负责人：
STEPHEN MATTHEW MALONE
金额：
$ 6.87万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-01 至 2011-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The overarching goals of this proposal are twofold: 1) to develop a programmatic line of research aimed at shedding light on the development of alcohol-related problems in adolescence and into adulthood using an intermediate phenotype maximum 24-hr alcohol consumption that has shown considerable promise as an indicator of risk in preliminary studies; and 2) to augment the applicant's training in developmental psychology with additional training in psychopathology, statistical methods for longitudinal data analysis, neuroscience, genetics (behavioral genetics, genetic epidemiology, and other quantitative methods), and advanced methods of event-related potential and magnetic resonance imaging analysis of brain structure and dynamics. The proposed research plan will build on findings that maximum consumption appears to relate more directly to the mechanisms conferring risk for SUDs than a psychiatric diagnosis of alcohol dependence and will use a developmentally and genetically-informed, multimethod approach to 1) evaluate the construct validity of the maximum consumption phenotype, 2) describe developmental trajectories among adolescent youth in relation to substance abuse risk and 3) to characterize neural dynamics among high-risk adolescents. The training activities will better prepare the applicant to conduct the proposed research, and the award would provide the freedom to pursue systematic research on this important phenotype. Together these will allow the applicant to pursue his ultimate goal as an independent researcher investigating neural processes associated with externalizing disorders and substance abuse. In addition, this research is likely to yield theoretically and clinically useful findings. It will extend previous research on electrophysiological correlates of substance abuse risk and ultimately holds significant promise for intervention efforts with high-risk individuals.

描述（由申请人提供）：该提案的总体目标有两个：1）开发一项计划性研究路线，旨在利用最大 24 小时的中间表型揭示青春期和成年期酒精相关问题的发展在初步研究中，饮酒作为风险指标显示出相当大的前景； 2）通过精神病理学、纵向数据分析统计方法、神经科学、遗传学（行为遗传学、遗传流行病学和其他定量方法）以及事件相关电位和磁的高级方法等方面的额外培训来增强申请人在发展心理学方面的培训大脑结构和动力学的共振成像分析。拟议的研究计划将建立在以下发现的基础上：与酒精依赖的精神病学诊断相比，最大消费似乎与赋予 SUD 风险的机制更直接相关，并将使用发育和遗传信息的多方法方法来 1）评估最大消耗表型，2) 描述青少年与药物滥用风险相关的发展轨迹，3) 描述高风险青少年的神经动态特征。培训活动将使申请人更好地准备进行拟议的研究，并且该奖项将提供对这一重要表型进行系统研究的自由。这些将使申请人能够作为一名独立研究人员追求他的最终目标，研究与外在疾病和药物滥用相关的神经过程。此外，这项研究可能会产生理论上和临床上有用的发现。它将扩展之前关于药物滥用风险的电生理学相关性的研究，并最终为高风险个体的干预工作带来重大希望。