MGH Large Animal Program Improvements

MGH 大型动物计划的改进

• 批准号: 6906094
• 负责人: RICHARD F BRINGHURST
• 金额: $ 62.45万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2008-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6906094
• 关键词: Primates; anesthesia; anesthetics; animal colony; biomedical facility; community; health; hospitals; housing; intensive care; lighting; medicine; monitoring device; occupational health /safety; pathology; postmortem; radiology; surgery; surgery material /equipment; ultrasound

DESCRIPTION (provided by applicant): The overall goals of the animal care and use program of the Massachusetts General Hospital (MGH) are to meet the needs of the institution's biomedical research community and its collaborators by 1) providing high quality laboratory animals of known health status and background; 2) providing animal husbandry and veterinary services in a functional viviarium; 3) assuring compliance of all animal- and occupational safety-related regulations and guidelines; and 4) maintaining a knowledgeable, compassionate and customer-responsive work force at all levels. The department at MGH that is responsible for animal husbandry, veterinary care, and other usual tasks is the Center for Comparative Medicine and Laboratory Animal Services (CCM). To meet these goals and accommodate an increasing number of research protocols requiring intensive and sophisticated veterinary care, greater security surveillance, and specialized caging, MGH is upgrading its large animal research capabilities and facilities. The specific aims of this submission are: 1. To improve pre- and peri-operative anesthesia during surgery and similar procedures, through the use of updated anesthesia equipment, anesthetic monitoring devices and surgery equipment (lights, tables, etc.). 2. To improve post-operative monitoring and support through the use of modem intensive care units and defibrillators. 3. To improve veterinary diagnostics by procuring clinical pathology analyzers, digital radiology, ultrasound, and necropsy equipment. 4. To assure a high level of security by installing digital surveillance cameras in all hallways and entrances to the large animal facility. 5. To enhance large animal, in particular nonhuman primate, housing with paired housing caging and additional environmental enrichment. 6. To update equipment used for handling conscious nonhuman primates to enhance animal welfare, minimize adverse effects on research data, and ensure personnel safety.

描述（由申请人提供）： 马萨诸塞州总医院 (MGH) 动物护理和使用计划的总体目标是通过以下方式满足该机构生物医学研究界及其合作者的需求：1) 提供已知健康状况和背景的高质量实验动物； 2）在功能齐全的动物园内提供畜牧业和兽医服务； 3）确保遵守所有与动物和职业安全相关的法规和指南； 4) 在各个层面维持一支知识渊博、富有同情心且对客户敏感的员工队伍。麻省总医院负责畜牧业、兽医护理和其他日常任务的部门是比较医学和实验动物服务中心 (CCM)。为了实现这些目标并适应越来越多需要密集和复杂的兽医护理、更严格的安全监控和专门笼养的研究方案，麻省总医院正在升级其大型动物研究能力和设施。本次提交的具体目的是： 1. 通过使用更新的麻醉设备、麻醉监测装置和手术设备（灯、手术台等），改善手术和类似手术期间的术前和围术期麻醉。 2. 通过使用现代重症监护病房和除颤器来改善术后监测和支持。 3. 通过采购临床病理分析仪、数字放射学、超声波和尸检设备来改进兽医诊断。 4. 在大型动物设施的所有走廊和入口处安装数字监控摄像头，确保高度安全。 5. 通过配对笼舍和额外的环境丰富来加强大型动物，特别是非人类灵长类动物的饲养。 6. 更新用于处理有意识的非人类灵长类动物的设备，以提高动物福利，尽量减少对研究数据的不利影响，并确保人员安全。