Imaging Hippocampal Function in Psychosis

精神病中海马功能的成像

• 批准号: 7014577
• 负责人: STEPHAN HECKERS
• 金额: $ 25.33万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-07 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7014577
• 关键词: behavior test; bioimaging /biomedical imaging; bipolar depression; brain imaging /visualization /scanning; brain morphology; clinical research; cognition disorders; data collection methodology /evaluation; functional magnetic resonance imaging; hippocampus; human subject; memory disorders; neuropsychology; prefrontal lobe /cortex; psychosis; schizophrenia

DESCRIPTION (provided by applicant): This is a revised proposal to study the structure and function of the hippocampal formation in psychosis. Hippocampal volume deficits are among the most robust brain abnormalities in chronic patients with schizophrenia. More recent studies have now established that hippocampal volume reduction is already present in the early stages of psychosis - in patients who develop schizophrenia as well as those who develop bipolar disorder. It is unclear, however, whether hippocampal pathology can explain the psychotic features or the well-known memory deficits in schizophrenia and bipolar disorder. Here the applicant is proposing to test the hypothesis that hippocampal dysfunction is necessary (but not sufficient) for the production of psychosis. Memory deficits are predicted to be prominent in schizophrenia and bipolar disorder because cortico-hippocampal interactions are perturbed in psychosis. To test this hypothesis, two groups of patients will be studied with novel morphometric and functional imaging approaches. First, two forms of hippocampal-dependent memory (i.e., the ability to remember episodes and the ability to infer relationships among items) will be studied in chronic patients with schizophrenia. This will allow the applicant to test the prediction that hippocampal dysfunction in conjunction with cortical and thalamic abnormalities can explain specific memory deficits in schizophrenia. Second, schizophrenic and bipolar patients will be studied at the time of their first hospitalization. Hippocampal function during episodic and relational memory task performance is predicted to be abnormal in the early stages of psychosis, whereas cortical dysfunction is less prominent compared to chronic patients with schizophrenia. The proposed studies are designed to elucidate the crucial role of hippocampal dysfunction for the production of psychosis and the development of cognitive deficits in schizophrenia and bipolar disorder.

描述（由申请人提供）：这是一项修订的建议，用于研究心理症中海马形成的结构和功能。海马体积缺陷是慢性精神分裂症患者中最强大的脑异常之一。现在，最近的研究表明，在精神病的早期阶段，海马体积减少已经存在 - 患有精神分裂症的患者以及患有双相情感障碍的患者。但是，尚不清楚海马病理学是否可以解释精神分裂症和躁郁症的精神病特征或众所周知的记忆缺陷。 在这里，申请人提议检验以下假设：海马功能障碍是必需（但不足）的精神病。预计记忆缺陷在精神分裂症和双相情感障碍中是突出的，因为皮质 - - 帕皮康相互作用在精神病中受到干扰。为了检验这一假设，将使用新型的形态计量学和功能成像方法研究两组患者。首先，将在慢性精神分裂症患者中研究两种形式的海马依赖性记忆（即记住发作的能力和推断项目之间的关系的能力）。这将使申请人能够测试海马功能障碍与皮质和丘脑异常结合的预测可以解释精神分裂症的特定记忆缺陷。其次，精神分裂症患者和双极患者将在他们第一次住院时进行研究。预计在精神病的早期阶段，在情节和关系记忆任务表现过程中的海马功能将异常，而与慢性精神分裂症患者相比，皮质功能障碍不太突出。 拟议的研究旨在阐明海马功能障碍在精神病的产生以及精神分裂症和躁郁症认知缺陷的发展中的关键作用。