Extinction and Active Coping Fear

灭绝和积极应对恐惧

基本信息

批准号：
7123377
负责人：
Elizabeth Anya Phelps
金额：
$ 22.82万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-24 至 2007-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7123377
关键词：
anxiety disorders behavioral /social science research tag behavioral extinction biological models clinical research coping emotions fear human subject laboratory rat model design /development psychobiology species difference

项目摘要

DESCRIPTION (provided by applicant): One of affective neuroscience is the of detailed animal models for fear learning that have been confirmed and extended in investigations with humans. The neural systems identified in these animal models, which have relied on fear conditioning as a basic paradigm, have been implicated in the development of psychological disorders, such as anxiety disorders and drug addiction. Understanding the neural circuits important for the development of these disorders is a first step in linking basic science to their treatment. The next step is to understand how these learned emotional responses can be extinguished or altered by action. The goal of the proposed research is to explore the neural mechanisms underlying the extinction and active coping of conditioned fear across human and non-human species and as they are altered with anxiety disorders. There are three specific aims: Aim 1: To develop paradigms of extinction and fear coping that are similar across species allowing for the exploration of specific neural mechanisms in rodents that can be assessed using less invasive techniques in humans. Aim 2: To determine the link between the neural mechanisms of fear inhibition through extinction with the mechanisms underlying active coping/emotion regulation strategies. Aim 3: To assess how the behavioral expression and neural mechanisms underlying fear extinction and active coping differs between normal subjects and patients suffering from anxiety disorders.

描述（由申请人提供）：情感神经科学之一是恐惧学习的详细动物模型，这些模型已在与人类的调查中得到了证实和扩展。这些动物模型中鉴定出的神经系统依赖于恐惧条件为基本范式，与心理疾病的发展有关，例如焦虑症和药物成瘾。了解对这些疾病发展重要的神经回路是将基础科学与他们的治疗联系起来的第一步。下一步是了解如何通过行动消灭或改变这些学习的情感反应。拟议的研究的目的是探索人类和非人类物种中条件恐惧的灭绝和积极应对的基础神经机制，并随着焦虑症的改变而改变。有三个特定的目标：目的1：开发灭绝和恐惧应对范式，这些范例在物种之间相似，允许探索啮齿动物中特定的神经机制，这些神经机制可以使用人类的侵入性较低的技术来评估。目的2：通过灭绝主动应对/情绪调节策略的机制来确定恐惧抑制的神经机制之间的联系。目标3：评估恐惧灭绝和主动应对的行为表达和神经机制如何在正常受试者和患有焦虑症患者的患者之间有所不同。