Prognostic significance of T wave variability

T波变异性的预后意义

基本信息

批准号：
7000353
负责人：
ERIC J RASHBA
金额：
$ 9.32万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-01-01 至 2006-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7000353
关键词：
arrhythmia bioimaging /biomedical imaging cardiovascular disorder epidemiology cardiovascular disorder prevention cardiovascular disorder risk diagnosis design /evaluation electrocardiography heart disorder diagnosis heart electrical activity human subject human therapy evaluation implant implantable defibrillators myocardial ischemia /hypoxia patient oriented research prognosis sudden cardiac death

项目摘要

DESCRIPTION (provided by applicant): The overall objective of this application is to support the principal investigator's development in a career focused on patient-oriented research. To accomplish this objective, the proposed program has both training and scientific components. The training component will consist of didactic coursework and preparation of a written thesis, culminating in a Master of Science degree in Clinical Investigation. This innovative degree program is offered by the Department of Epidemiology and Preventive Medicine at the University of Maryland. The coursework will provide training in clinical research methods including biostatistics, responsible research conduct, clinical epidemiology, and design and implementation of research studies. The scientific component of the proposal is focused on the primary prevention of sudden cardiac death. Sudden cardiac death remains a common clinical problem in the United States, with over 350,000 deaths annually. Patients with left ventricular systolic dysfunction are at particularly high risk for the ventricular arrhythmias that precipitate sudden cardiac death. The goal of this research is to develop a new method to identify those patients with systolic dysfunction who are most likely to suffer malignant ventricular arrhythmias. If a high-risk subgroup can be identified, these patients are likely to benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). This proposal is focused on the development of two novel risk stratification techniques that independently quantify dynamic changes in ventricular repolarization: T wave variability and T wave alternans. The scientific program will test the following hypotheses: 1) T wave variability and T wave alternans are both predictors of arrhythmic events among patients with ischemic cardiomyopathy. 2) Patients with increased T wave variability derive a greater mortality benefit from prophylactic ICD implantation.

描述（由申请人提供）：该应用程序的总体目的是支持校长研究者在专注于以患者为导向的研究的职业生涯中的发展。为了实现这一目标，拟议的计划既有培训，又有科学组成部分。培训组件将包括教学成分课程工作和书面论文的准备，最终在临床研究的科学学位。这个创新的学位课程是由流行病学和预防医学系提供马里兰大学。该课程将提供临床培训研究方法，包括生物统计学，负责任的研究行为，临床流行病学以及研究研究的设计和实施。这该提案的科学组成部分的重点是主要预防突然心脏死亡。猝死仍然是一个常见的临床问题在美国，每年有35万多人死亡。左患者心室收缩功能障碍的风险尤其高心室心律不齐，导致心脏猝死。目标这项研究是开发一种新方法来识别那些患者收缩功能障碍，最有可能患有恶性心室心律不齐。如果可以确定高风险的亚组，这些患者是可能受益于预防性治疗心脏逆转表纤颤器（ICD）。该提议的重点是发展独立量化的两种新型风险分层技术心室复极的动态变化：T波变异性和T波替代人。科学计划将检验以下假设：1）T 波变异性和T波替代品都是心律不齐事件的预测指标在缺血性心肌病的患者中。 2）t增加的患者波变异性从预防性ICD获得更大的死亡率。植入。