Career Training in Marijuana Dependence

大麻依赖职业培训

• 批准号: 7107183
• 负责人: AIMEE L MCRAE-CLARK
• 金额: $ 13.84万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-29 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7107183
• 关键词: anxiety; behavior therapy; behavioral /social science research tag; buspirone; cannabinoids; clinical research; clinical trial phase I; combination therapy; craving; drug abuse chemotherapy; drug screening /evaluation; human subject; human therapy evaluation; marijuana abuse; mood disorders; motivation; patient oriented research; pharmacokinetics; urinalysis

DESCRIPTION (provided by applicant): This application for a Mentored-Patient Oriented Research Career Development Award is designed to prepare the candidate for a career in clinical research in drug use disorders with a special emphasis on marijuana use, abuse, and dependence. The training plan involves course work, supervised readings, and "hands on" experience with leading experts in the pharmacology of cannabinoids and the treatment of marijuana dependence. There is a disconnect between the advances in the pharmacology and basic science of cannabinoids and clinical research in this area. By studying both basic science and clinical aspects, the candidate will be well-positioned to design and carry out methodologically sound patient-oriented research with a strong theoretical background. Developing this well-rounded perspective and expertise in the area of cannabinoids and marijuana abuse and dependence is the aim of the training plan outlined. The proposed research project integrates the candidate's experience in conducting pharmacotherapeutic trials with newly developed skills in motivational interviewing. The clinical research that has been conducted in the area of marijuana use and dependence has almost exclusively focused on psychotherapeutic interventions, including motivational interviewing. However, recent neuroscientific advances, such as the discovery of the cannabinoid receptors, suggest that pharmacotherapeutic strategies for treating marijuana dependence should be explored in conjunction with psychotherapeutic interventions. As anxiety may play a key role in marijuana abuse anxiolytic medications in particular may prove useful in reducing marijuana use. The hypothesis to be tested in the proposed research project is whether buspirone, an anxiolytic medication, will increase efficacy in reducing marijuana use in marijuana-dependent patients when delivered with motivational interviewing. The study will be a 12-week, randomized, double-blind, placebo-controlled trial evaluating a flexible dose of buspirone or placebo in combination with motivational interviewing. The primary outcome measure will be marijuana use as assessed by self-report and weekly urine drug screens. The results of this study will help guide future directions for research in the area of marijuana dependence.

描述（由申请人提供）：该申请申请受过指导的患者研究职业发展奖旨在为候选药物临床研究的候选人做好准备，并特别着重于大麻使用，滥用和依赖。 培训计划涉及课程工作，有监督的阅读以及与大麻素药理学和大麻依赖治疗的领先专家的“动手”经验。 大麻素的药理学和基础科学的进步与该领域的临床研究的进步之间存在脱节。 通过研究基础科学和临床方面，候选人将有充分的设计，以设计和进行具有强大理论背景的方法论性良好的以患者为导向的研究。 在大麻素和滥用大麻和依赖方面发展了这种全面的观点和专业知识，这是概述的培训计划的目的。 拟议的研究项目将候选人在进行药物治疗试验方面的经验与新开发的动机访谈技能。 在大麻使用和依赖方面进行的临床研究几乎完全集中在心理治疗干预措施上，包括动机访谈。 然而，最近的神经科学进展，例如发现大麻素受体，表明应与心理治疗干预措施一起探索治疗大麻依赖性的药物治疗策略。 由于焦虑症在滥用大麻中的关键作用尤其可能被证明可用于减少大麻使用。 在拟议的研究项目中要检验的假设是，抗焦虑药的胰蛋白酶是否会在进行动机访谈的情况下增加大麻依赖大麻依赖性患者的疗效。 这项研究将是一项为期12周的，随机的，双盲的，安慰剂对照试验，评估了弹性辅助剂量的灵活剂量，并与动机访谈结合使用。 如自我报告和每周的尿液药物筛查所评估的，主要结果是使用大麻。 这项研究的结果将有助于指导大麻依赖领域研究的未来方向。

项目成果

Assessment of club drug use in a treatment-seeking sample of individuals with marijuana dependence.

对寻求治疗的大麻依赖个体样本中的俱乐部药物使用情况进行评估。

• DOI: 10.1080/10550490701643450
• 发表时间: 2007
• 期刊: The American journal on addictions
• 作者: Verduin,MarciaL;Payne,RebeccaA;McRae,AimeeL;Back,SudieE;Simpson,StaceyA;Sarang,RajeshY;Brady,KathleenT
• 通讯作者: Brady,KathleenT