The Role of Inflammation and Parity on GDM and Type 2 DM

炎症和产次对 GDM 和 2 型 DM 的作用

• 批准号: 7107863
• 负责人: Wanda K Nicholson
• 金额: $ 13.41万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7107863
• 关键词: acute phase protein; clinical research; diabetes risk; female; gestational diabetes mellitus; glucose tolerance; human pregnant subject; inflammation; interleukin 6; longitudinal human study; meta analysis; noninsulin dependent diabetes mellitus; parity; patient oriented research; tumor necrosis factor alpha

DESCRIPTION (provided by applicant): Wanda K. Nicholson, MD, MPH is seeking this K23 award to study the role of inflammatory markers as predictors of gestational diabetes mellitus (GDM) and incident Type 2 diabetes mellitus (Type 2 DM), to complete advanced training in the conduct of longitudinal studies, and to transition to an independent career in clinical research. Dr. Nicholson is an Assistant Professor in the Department of Gynecology and Obstetrics at Johns Hopkins and has fellowship training in clinical research and an early track record of peer reviewed clinical research. Parity has been previously linked to Type 2 DM; however, the underlying mechanism for this association is unclear. Recently, markers of inflammation (e.g. C-reactive protein) have emerged as independent predictors of Type 2 DM. No studies have examined whether the association of parity with Type 2 DM is mediated by the presence of inflammation. Moreover, it is unclear whether inflammatory markers are also predictors of GDM. She proposes to determine the effect of parity and inflammatory markers on prevalent and incident cases of Type 2 DM through cross-sectional and case-cohort analyses of the NHANES III and ARIC data, respectively. In addition, a prospective case-cohort study will assess inflammatory markers as risk predictors of GDM. This proposal will provide an in-depth examination of the role of parity and inflammatory markers in the pathogenesis of GDM and Type 2 DM. During this award, Dr. Nicholson will gain new skills and knowledge in the research methods for prospective study design, multivariate assessment of risk factors and longitudinal data analysis. The combination of observational research, primary data collection and advanced educational training will provide the basis for further prospective studies integrating the relation of parity and inflammation to GDM and Type 2 DM. This award will give Dr. Nicholson the dedicated time and experience she needs to develop into an independent clinical investigator

描述（由申请人提供）： MPH的Wanda K. Nicholson医学博士正在寻求这一K23奖，以研究炎症标记作为妊娠糖尿病（GDM）（GDM）和事件2型糖尿病（2型DM）的预测因素（2型DM），以完成漫长研究的行为，以及过渡到独立职业的过渡。尼科尔森（Nicholson）博士是约翰·霍普金斯（Johns Hopkins）的妇科和妇产科系助理教授，并在临床研究中接受了奖学金培训，并且是同行评审的临床研究的早期记录。以前已将奇偶校验链接到2型DM；但是，这种关联的基本机制尚不清楚。最近，炎症的标记（例如C反应蛋白）已成为2型DM的独立预测指标。尚无研究检查均衡与2型DM的关联是否是由炎症的存在介导的。此外，尚不清楚炎症标记是否也是GDM的预测指标。她建议通过分别对NHANES III和ARIC数据的横截面和案例 - 核心分析来确定均衡和炎症标记对2型DM的普遍和事件案例的影响。此外，一项前瞻性病例研究将评估炎症标志物作为GDM的风险预测因子。该建议将对奇偶校验和炎症标记在GDM和2型DM发病机理中的作用进行深入研究。在此奖项期间，尼科尔森博士将在前瞻性研究设计，危险因素的多元评估和纵向数据分析的研究方法中获得新的技能和知识。观察研究，主要数据收集和先进的教育培训的结合将为进一步的前瞻性研究提供基础，从而将平等和炎症与GDM和2型DM的关系整合在一起。该奖项将为尼科尔森博士提供她发展成独立临床研究者所需的专门时间和经验