Hypothalamic fMRI response to nutrients
下丘脑功能磁共振成像对营养物质的反应
基本信息
- 批准号:7213783
- 负责人:
- 金额:$ 20.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-20 至 2008-07-31
- 项目状态:已结题
- 来源:
- 关键词:bioimaging /biomedical imagingbody weightbrain electrical activitybrain stemclinical researchdietary lipidfructosefunctional magnetic resonance imagingglucosehuman subjecthypothalamusintravenous administrationneuroregulationnutrient intake activitynutrition related tagobesitypathogenic dietstatistics /biometryweight gain
项目摘要
DESCRIPTION (provided by applicant): Animal studies have established the importance of the hypothalamus in the control of appetite and energy expenditure. Nuclei within this area of the brain integrate inputs from adipose tissue reflecting body fat stores and the gastrointestinal tract reflecting the amount and types of food ingested. These afferent signals trigger changes in food intake and energy expenditure through mechanisms involving both immediate alterations in neuronal cell electrical activity and relatively slower effects mediated via hormone-receptor binding. While these concepts of a central integrative center controlling weight regulation are well studied in animal models, the importance of these findings to humans is less clear. This is in large part due to a lack of tools available to study neuronal responses to various effectors in-vivo in humans. Functional nuclear magnetic imaging (fMRI) is a non-invasive, non-radioactive imaging technique that detects real-time changes in neuronal electrical activity to within a few millimeters in the brain. fMRI has been used to study the brain's response to ingestion of glucose and shown differences in this response between lean and obese subjects. However, questions remain regarding the specificity of these differences for nutrients (as opposed to gut hormones) and interactions of different macronutrients with central centers involved in weight regulation in humans. The proposals in this pilot grant will bring together investigators with backgrounds in clinical research, basic electrophysiological and neuroendocrine mechanisms of obesity, and fMRI imaging to better understand how nutrients affect brain activity in hypothalamic and brainstem regions involved with weight regulation in humans. The first aim will use fMRI to determine hypothalamic and brainstem responses to intravenous glucose and fructose in lean and obese subjects. The second aim will determine if lipids affect central glucose responsiveness as suggested by weight gain on high-fat diets in rodent models. Experience and data gained from these studies will be used in future proposals of effects on brain activity to mixed meals, long-term feeding of diets of differing macronutrient content, as well as to infusions of individual and combinations of gut-derived hormones secreted in response to meals and adipocyte hormones such as leptin. Simultaneous sampling of blood for levels of nutrients, insulin, leptin, and other hormones involved in weight regulation will give insight into the role they may play in changes in fMRI signaling in weight regulation centers in the brain. Lay Description: This study will use functional MRI scanning to explore how the brain is affected by sugar and fat. These studies will help us to better understand why changes in the diet might lead to weight gain or loss.
描述(由申请人提供):动物研究已经确定了下丘脑在控制食欲和能量消耗方面的重要性。大脑该区域内的细胞核整合来自反映身体脂肪储存的脂肪组织和反映摄入食物的数量和类型的胃肠道的输入。这些传入信号通过涉及神经元细胞电活动的立即改变和通过激素受体结合介导的相对较慢的影响的机制触发食物摄入和能量消耗的变化。虽然控制体重调节的中央综合中心的概念在动物模型中得到了充分研究,但这些发现对人类的重要性尚不清楚。这在很大程度上是由于缺乏可用于研究人类体内神经元对各种效应器的反应的工具。功能性核磁成像 (fMRI) 是一种非侵入性、非放射性成像技术,可检测大脑中几毫米范围内神经元电活动的实时变化。功能磁共振成像已被用来研究大脑对葡萄糖摄入的反应,并显示出瘦人和肥胖受试者之间这种反应的差异。然而,关于营养素(相对于肠道激素)的这些差异的特异性以及不同常量营养素与参与人类体重调节的中枢的相互作用的问题仍然存在。该试点拨款中的提案将汇集具有临床研究、肥胖的基本电生理学和神经内分泌机制以及功能磁共振成像背景的研究人员,以更好地了解营养物质如何影响与人类体重调节有关的下丘脑和脑干区域的大脑活动。第一个目标是使用功能磁共振成像来确定瘦和肥胖受试者的下丘脑和脑干对静脉注射葡萄糖和果糖的反应。第二个目标将确定脂质是否影响中枢葡萄糖反应性,正如啮齿动物模型中高脂肪饮食体重增加所表明的那样。从这些研究中获得的经验和数据将用于未来关于混合膳食、长期喂养不同常量营养素含量的饮食以及注射相应的肠道源性激素的个体和组合对大脑活动的影响的建议。膳食和脂肪细胞激素(例如瘦素)。同时对血液进行采样,检测营养素、胰岛素、瘦素和其他与体重调节有关的激素的水平,将有助于深入了解它们在大脑体重调节中心功能磁共振成像信号变化中所发挥的作用。外行描述:这项研究将使用功能性核磁共振扫描来探索糖和脂肪如何影响大脑。这些研究将帮助我们更好地理解为什么饮食的改变可能会导致体重增加或减轻。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JONATHAN Q. PURNELL其他文献
JONATHAN Q. PURNELL的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JONATHAN Q. PURNELL', 18)}}的其他基金
LABS Sub-study: Mechanisms of Durability of Type 2 Diabetes Remission
LABS 子研究:2 型糖尿病缓解持久机制
- 批准号:
9097691 - 财政年份:2014
- 资助金额:
$ 20.22万 - 项目类别:
LABS Sub-study: Mechanisms of Durability of Type 2 Diabetes Remission
LABS 子研究:2 型糖尿病缓解持久机制
- 批准号:
8800570 - 财政年份:2014
- 资助金额:
$ 20.22万 - 项目类别:
Regulation of Brain Signaling After Bariatric Surgery
减肥手术后大脑信号的调节
- 批准号:
8038527 - 财政年份:2010
- 资助金额:
$ 20.22万 - 项目类别:
Structure and Regulation of Ghrelin in Obesity
肥胖中 Ghrelin 的结构和调节
- 批准号:
8150032 - 财政年份:2007
- 资助金额:
$ 20.22万 - 项目类别:
Structure and Regulation of Ghrelin in Obesity
肥胖中 Ghrelin 的结构和调节
- 批准号:
7586816 - 财政年份:2007
- 资助金额:
$ 20.22万 - 项目类别:
Structure and Regulation of Ghrelin in Obesity
肥胖中 Ghrelin 的结构和调节
- 批准号:
7385049 - 财政年份:2007
- 资助金额:
$ 20.22万 - 项目类别:
Structure and Regulation of Ghrelin in Obesity
肥胖中 Ghrelin 的结构和调节
- 批准号:
7258538 - 财政年份:2007
- 资助金额:
$ 20.22万 - 项目类别:
CHANGE IN LEPTIN AS A PREDICTOR OF SATIETY WITH HIGH PROTEIN FEEDING
瘦素的变化是高蛋白喂养饱腹感的预测因子
- 批准号:
7206570 - 财政年份:2005
- 资助金额:
$ 20.22万 - 项目类别:
相似国自然基金
基于PI3K/AKT通路研究奥氮平所致精神分裂症体重增加的认知神经机制
- 批准号:82371512
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
蛋白酶体重要调控分子NFE2L1在子宫内膜蜕膜化中的作用和机制研究
- 批准号:82301894
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
多房棘球绦虫钙网蛋白EmCRT与补体重要组分C1q结合位点的定位及功能研究
- 批准号:82360403
- 批准年份:2023
- 资助金额:32 万元
- 项目类别:地区科学基金项目
中轨道SAR对高海情下舰船目标认知成像与多维信息立体重构
- 批准号:62371170
- 批准年份:2023
- 资助金额:50 万元
- 项目类别:面上项目
孕期夜光暴露对新生儿出生体重的影响及其通过褪黑素调节胎盘mTOR信号通路的机制研究
- 批准号:82373536
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
相似海外基金
Integrated Interdisciplinary Training in Computational Neuroscience
计算神经科学综合跨学科培训
- 批准号:
7293610 - 财政年份:2006
- 资助金额:
$ 20.22万 - 项目类别:
Impaired Brain-Leptin Interaction in Chronic Tobacco Us*
慢性吸烟者大脑与瘦素相互作用受损*
- 批准号:
6594124 - 财政年份:2002
- 资助金额:
$ 20.22万 - 项目类别:
Regulation of Amphetamine Reward by Central Insulin
中枢胰岛素对安非他明奖励的调节
- 批准号:
6663757 - 财政年份:2002
- 资助金额:
$ 20.22万 - 项目类别: