Gene Suppression: Drug Target Validation

基因抑制：药物靶点验证

• 批准号: 6582487
• 负责人: Peter B Dervan
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-17 至 2004-01-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6582487
• 关键词: drug design /synthesis /production; gene expression; gene induction /repression; meeting /conference /symposium; pharmacokinetics; travel

DESCRIPTION (provided by applicant): There is an enormous interest in the application of diverse chemical and biological tools to control the expression of specific genes or compromise the activities of specific mRNAs and proteins. The biotechnology industry develops these tools for plant and animal engineering, the pharmaceutical industry makes use of these tools to validate drug targets, and the medical community investigates a subset of these reagents as therapeutics in their own right. The purpose of this Keystone Symposium is to review the utility of chemical and biological approaches to selectively turning gene activity off at the transcriptional, post-transcriptional and protein level- especially with reference to functional genomics. The aim is to provide a broad overview of established and emerging methodologies, the basic science behind these approaches and their utility from an industrial and medical perspective. The availability of the human genome and widespread use of micro array strategies for assessing specificity should make the meeting especially timely and provide a unifying focus by 2003. The latest advances on RNA interference, protein engineering to repress transcription, chemical approaches to gene control, antisense, ribozymes and knockout strategies will be discussed.

描述（由申请人提供）：人们对应用各种化学和生物工具来控制特定基因的表达或损害特定 mRNA 和蛋白质的活性产生了巨大的兴趣。生物技术行业为植物和动物工程开发这些工具，制药行业利用这些工具来验证药物靶标，医学界研究这些试剂的一部分作为其本身的治疗方法。本次 Keystone 研讨会的目的是回顾化学和生物学方法在转录、转录后和蛋白质水平上选择性关闭基因活性的实用性，特别是在功能基因组学方面。目的是从工业和医学的角度提供对现有和新兴方法、这些方法背后的基础科学及其实用性的广泛概述。人类基因组的可用性和用于评估特异性的微阵列策略的广泛使用应该使这次会议特别及时，并在 2003 年之前提供统一的焦点。RNA 干扰、抑制转录的蛋白质工程、基因控制的化学方法、反义的最新进展、核酶和敲除策略将被讨论。