Reactive Intermediates: The Vanguard

反应中间体：先锋

• 批准号: 6720933
• 负责人: JAMES C FISHBEIN
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6720933
• 关键词: biochemistry; free radicals; meeting /conference /symposium; toxicology; travel

DESCRIPTION (provided by applicant): This application seeks support for a half-day symposium to be held at the 226th meeting of the American Chemical Society September 8-10, 2003 in New York City that is sponsored by the Division of Chemical Toxicology. The Symposium is titled: "Reactive Intermediates: The Vanguard" and seeks to focus on the latest novel chemistry relevant to chemical damage in human health. Certainly the complex etiology of many diseases, including cancers, is initiated by chemical damage to biomolecules; lipids, proteins and DNA. Over the last thirty years, considerable progress has been made in characterizing types of damage from a variety of sources both environmental and endogenous. While in some select cases, a reasonably straightforward picture of the underlying chemical events has emerged, it has become increasingly apparent that there is considerable chemical complexity in what ultimately constitutes damage that may affect disease. The initial, or primary, damage may in fact evolve in a series of subsidiary damage events. These subsidiary events may ultimately be responsible for, intensify or otherwise modulate the "initiating" event. Both the initial event and the subsidiary events are mediated by reactive intermediates. Understanding the fundamental aspects of the chemistry of these intermediates, their structure, reactivity and reaction products, is essential in dissecting the species that ultimately give rise to key damage events that devolve to the morbid state. The purpose of this symposium is to bring together leading chemists who are involved in the understanding the spectrum of primary and subsidiary reactive intermediates and the chemistry that gives rise to cellular damage that initiates disease, particularly cancer.

说明（由申请人提供）：本申请寻求支持将于 2003 年 9 月 8 日至 10 日在纽约市举行的美国化学会第 226 届会议上举行的半天研讨会，该会议由化学毒理学部主办。 研讨会的标题是：“反应中间体：先锋”，旨在重点关注与人类健康化学损害相关的最新新型化学。 当然，包括癌症在内的许多疾病的复杂病因都是由生物分子的化学损伤引起的。脂质、蛋白质和DNA。 在过去的三十年中，在表征各种环境和内源性损害类型方面已经取得了相当大的进展。 虽然在某些特定情况下，基本化学事件的相当简单的图景已经出现，但越来越明显的是，最终构成可能影响疾病的损害的化学复杂性相当大。 最初的或主要的损害实际上可能会演变为一系列次要损害事件。 这些附属事件可能最终导致、加剧或以其他方式调节“起始”事件。 初始事件和附属事件都是由反应中间体介导的。 了解这些中间体化学的基本方面、它们的结构、反应性和反应产物，对于剖析最终导致转变为病态状态的关键损伤事件的物种至关重要。 本次研讨会的目的是聚集领先的化学家，他们致力于了解主要和辅助反应中间体的范围，以及引起细胞损伤、引发疾病（特别是癌症）的化学物质。