Integrated Myocardial Ischemia Assessment with MRI

MRI 综合心肌缺血评估

• 批准号: 7009911
• 负责人: John M. Pauly
• 金额: $ 36.87万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-10 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7009911
• 关键词: asthma; biotechnology; cardiovascular disorder epidemiology; chronic obstructive pulmonary disease; clinical research; cooperative study; functional /structural genomics; genetic mapping; genetic polymorphism; genetic screening; genetic susceptibility; human subject; immunogenetics; myocardial infarction; racial /ethnic difference; respiratory disorder epidemiology; venous thrombosis

DESCRIPTION (provided by applicant): Patients with chest pain suffer from inadequate blood supply to the heart. This "myocardial ischemia" is reflected in changes in many physiologic parameters, including coronary flow reserve and myocardial contractile reserve. Perfusion imaging and stress-induced wall motion are the most commonly used clinical tests for ischemia assessment. Unfortunately these current clinical standards are known to have significant inaccuracy due to fundamental issues of image resolution and image quality. Improving the clinical assessment of myocardial ischemia will be enormously important since there are more than 3 million studies are conducted each year. Magnetic resonance imaging is potentially able to overcome all the known technical difficulties associated with the current techniques. While raw image acquisition speed has improved significantly, the goal of assessing myocardial contraction and perfusion volumetrically during an induced 60-90 second time window of true ischemia is far from being realized. This is primarily limited by inadequate imaging speed. It is also hindered by the inability to adjust, in real-time, the scan volume during the course of the study. In this proposal, we will develop an integrated examination of cardiac ischemia that will allow for real-time interactive evaluation of myocardial contraction and perfusion at 24 true frames/second/slice over at least 3 slices. It is expected that this research will have a significant impact on the accuracy of clinical ischemia assessment.

描述（由申请人提供）：胸痛患者的血液供应不足。这种“心肌缺血”反映在许多生理参数的变化中，包括冠状动脉流量储备和心肌收缩储备。灌注成像和应力诱导的壁运动是最常用的缺血评估临床测试。不幸的是，由于图像分辨率和图像质量的基本问题，这些当前的临床标准众所周知存在明显的不准确性。由于每年进行超过300万项研究，改善心肌缺血的临床评估将非常重要。磁共振成像可能能够克服与当前技术相关的所有已知技术困难。虽然原始图像采集速度有了显着提高，但在感应的60-90秒第二秒窗口中，对心肌收缩和灌注进行体积评估的目的远未实现。这主要受到成像速度不足的限制。在研究过程中无法实时调整扫描量，这也使它受到阻碍。在此提案中，我们将开发对心脏缺血的综合检查，这将允许在24个真实帧/秒/秒/秒至少在至少3个切片上对心肌收缩和灌注进行实时互动评估。预计这项研究将对临床缺血评估的准确性产生重大影响。

项目成果

A practical acceleration algorithm for real-time imaging.

• DOI: 10.1109/tmi.2009.2030474
• 发表时间: 2009-12
• 期刊: IEEE transactions on medical imaging
• 影响因子: 10.6
• 作者: Sümbül U;Santos JM;Pauly JM
• 通讯作者: Pauly JM

Improved time series reconstruction for dynamic magnetic resonance imaging.

• DOI: 10.1109/tmi.2008.2012030
• 发表时间: 2009-07
• 期刊: IEEE transactions on medical imaging
• 影响因子: 10.6
• 作者: Sümbül U;Santos JM;Pauly JM
• 通讯作者: Pauly JM