Psychoneuroimmunology, Stress, and Healthy Aging in Hispanics

西班牙裔的心理神经免疫学、压力和健康老龄化

• 批准号: 6924533
• 负责人: Victor S Sierpina
• 金额: $ 45.3万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6924533
• 关键词: Hispanic Americans; aging; alternative medicine; attitude; behavior therapy; behavioral /social science research tag; behavioral medicine; biomarker; clinical research; coping; cortisol; health behavior; home for elderly; human old age (65+); human subject; human therapy evaluation; interleukin 10; interleukin 6; music therapy; nursing homes; patient oriented research; psychoneuroimmunology; quality of life; stress

DESCRIPTION (provided by applicant): This is a multi-level, multi-disciplinary, and interdisciplinary project to examine stress and coping in older adults with a focus on Hispanic seniors. Using mixed qualitative and quantitative methodologies, biological measures of stress (cortisol, IL-6, IL-10), along with attitudinal and quality of life measures, we will investigate the psychoneuroimmunology (PNI) of stress and coping in three settings. These are: an inpatient rehabilitation setting in which music therapy will be used as stress mitigating intervention; a Mexican American community setting located near a large petrochemical complex; and nursing home and assisted living extended care facilities. Four pilot projects are described that expand the scope of questions and measures of existing funded projects. A developmental project is proposed to assess the factors causing translational blocks between the research supporting mind-body medicine (MBM), its clinical application, and its utility as a community intervention. Two core components are proposed. The first is an administrative infrastructure, the Integrative Medicine and Biobehavioral Research Section (IMBRS) including an academic and computer core housing resources and informatics capacities in MBM. The second component is a longitudinal investigator development project to develop mentoring relationships, provide essential research skills in MBM, acquire the tools and techniques of clinical research, and to develop technical writing and grantsmanship competencies. We anticipate that this multi-layered approach will result in increased capacity at UTMB to produce high quality MBM research, to qualify for future funding, and to produce a cadre of interdisciplinary MBM researchers. By building on our existing projects and our strengths in the study of Hispanic populations, we believe this is a unique and broad based project with high likelihood of success. Through these efforts we expect to favorably impact health care outcomes of our patient population through enhanced understanding of the principles of MBM, PNI, stress and coping mechanisms in healthy aging in older Hispanics. We will also generate new studies in the field of MBM related not only to Geriatrics but also to other populations and age ranges.

描述（由申请人提供）：这是一个多层次、多学科和跨学科的项目，旨在研究老年人的压力和应对方式，重点关注西班牙裔老年人。使用混合定性和定量方法、压力的生物测量（皮质醇、IL-6、IL-10）以及态度和生活质量测量，我们将研究三种环境下压力和应对的心理神经免疫学 (PNI)。这些是： 住院康复环境，其中音乐疗法将用作缓解压力的干预措施；位于大型石化厂附近的墨西哥裔美国人社区；疗养院和辅助生活延伸护理设施。描述了四个试点项目，扩大了现有资助项目的问题和措施的范围。建议开展一项开发项目，以评估导致心身医学 (MBM) 支持研究、其临床应用及其作为社区干预的效用之间转化障碍的因素。提出了两个核心组件。第一个是行政基础设施，即综合医学和生物行为研究科 (IMBRS)，包括学术和计算机核心住房资源以及 MBM 的信息学能力。第二个组成部分是纵向研究者发展项目，旨在发展指导关系，提供 MBM 的基本研究技能，获得临床研究的工具和技术，并发展技术写作和资助能力。我们预计，这种多层次的方法将提高 UTMB 进行高质量 MBM 研究的能力，以获得未来资助的资格，并培养一支跨学科 MBM 研究人员的骨干队伍。通过以我们现有的项目和我们在西班牙裔人口研究方面的优势为基础，我们相信这是一个独特且基础广泛的项目，成功的可能性很高。通过这些努力，我们期望通过加深对老年西班牙裔健康老龄化过程中 MBM、PNI、压力和应对机制的理解，对患者群体的医疗保健结果产生积极影响。我们还将在肉骨粉领域开展新的研究，不仅与老年病学相关，还与其他人群和年龄范围相关。