Tolerance, Autoimmunity and Immune Regulation

耐受性、自身免疫和免疫调节

• 批准号: 7058889
• 负责人: David W. Scott
• 金额: $ 1.25万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058889
• 关键词: autoimmunity; immune tolerance /unresponsiveness; immunity; meeting /conference /symposium; travel

Understanding how the immune system breaks down tolerance to self is critical to controlling and, indeed, reversing autoimmune diseases like type 1 diabetes, multiple sclerosis, and lupus. This meeting will bring together experts in basic immunology and clinical science, as well as the biotech world, to present the latest data and prospects for treatment of these debilitating diseases. Self versus non-self discrimination is one of the basic tenets of immunology. The pathways by which tolerance is established are complex but recent work has provided greater insight into this important process. Understanding how tolerance is induced and "broken" is critical to developing future therapies for a variety of autoimmune disorders, such as diabetes and multiple sclerosis. Novel approaches need to be developed for the treatment of the autoimmune disorders that lead to tissue target cell destruction. This Keystone meeting is centered at understanding tolerance and its breakdown, and bridging the gap between basic, pre-clinical and clinical studies. While there will be an emphasis on basic studies, disease models for dissecting pathogenesis and examining novel therapies in a variety of autoimmune diseases (e.g., diabetes, multiple sclerosis, IBD, uveitis, as well as hemophilia), which will provide a major focus. Thus, a major theme will be the underlying tolerance pathways, as well as how they are subverted. The establishment of new models and therapies, including human clinical trials, will be included. Sessions to be covered include studies of the genes and signals involved in tolerance and autoimmunity, the interaction of the innate and adaptive immune systems, novel approaches for tolerance induction in autoimmune, models, and translation of these to human clinical trials. Proof of principle studies and new biotechnology approaches will also be emphasized. The goals of the meeting are: To provide an understanding of the mechanisms of immune tolerance and its breakdown;To update the audience on autoimmune models and clinical trials; To stimulate interactions between basic and clinical scientists, as well as R & D scientists in industry; from around the globe to collaborate to respond to the challenges in this area; A novel feature this year is the addition of a formal debate session in the evening of the second day, as well as the presentation of the Lifetime Achievement Awards, with a brief historical overview. Workshops will be designed to be interactive rather than shorter plenary-type talks.

了解免疫系统如何破坏对自我的宽容对于控制至关重要，实际上是逆转自身免疫性疾病，例如1型糖尿病，多发性硬化症和狼疮。这次会议将汇集基本免疫学和临床科学以及生物技术世界的专家，以介绍治疗这些衰弱疾病的最新数据和前景。自我与非自我歧视是免疫学的基本原则之一。建立公差的途径是复杂的，但是最近的工作为这一重要过程提供了更深入的洞察力。了解耐受性是如何诱导的，并且“破碎”对于开发各种自身免疫性疾病（例如糖尿病和多发性硬化症）的未来疗法至关重要。需要开发新的方法来治疗导致组织靶细胞破坏的自身免疫性疾病。这次Keystone会议 以理解耐受性及其分解为中心，并弥合基本，临床前和临床研究之间的差距。虽然将重点放在基础研究上，但剖析发病机理并检查各种自身免疫性疾病的新疗法（例如糖尿病，多发性硬化症，IBD，葡萄膜炎以及血友病）的疾病模型，这将提供主要的重点。因此，一个主要的主题将是潜在的宽容途径，以及它们的颠覆方式。包括人类临床试验在内的新模型和疗法的建立将包括在内。要涵盖的课程包括对耐受性和自身免疫性涉及的基因和信号的研究，先天性和适应性免疫系统的相互作用，自身免疫性耐受性诱导的新方法，模型以及这些转化为人类临床试验。还将强调原理研究证明和新的生物技术方法。会议的目标是：提供对免疫耐受性机制及其故障的理解；以对自身免疫模型和临床试验更新受众；刺激基本科学家和临床科学家以及行业的研发科学家之间的互动；从全球各地进行合作，以应对这一领域的挑战；今年的一项新颖功能是第二天晚上的正式辩论会议以及终身成就奖的介绍以及简短的历史概述。讲习班将设计为互动，而不是较短的全体式演讲。