Mechanotransduction & Gravity Signaling in Biol Systems

力传导

• 批准号: 6894064
• 负责人: MARTIN CHALFIE
• 金额: $ 2.59万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6894064
• 关键词: biological signal transduction; gravity; meeting /conference /symposium; sensory mechanism; travel

DESCRIPTION (provided by applicant): The 8th and 9th biennial Gordon Research Conference on "Mechanotransduction and Gravity Signaling in Biological Systems" will be held July 20-25, 2003 and July 22-27, 2005, respectively, at Connecticut College. The theme of the meeting is mechanosensing, an ancient sensory capability. About 100 participants are expected, including 25 speakers and 13 discussion leaders. Funding is requested to support 20 junior-level participants. This is an exciting time for research on mechanosensation. The field is rapidly growing, especially in the area of genetic approaches to mechanotransduction. A strikingly well supported model has been proposed to explain the gating of a prokaryotic mechanosensitive channel. Eukaryotic genetic model systems including worm and fruitfly have identified two classes of putative mechanosensory channels, DEG/EnaC and TRP channels, that are now being directly tested for mechanical gating properties. Analysis of hearing defective mutants in zebrafish, mice, and humans is accelerating with the identification of new proteins important for hair cell and auditory function. In addition to work on specialized sensors, there are major advances in our understanding of mechanosensing in nonspecialized tissues (bone, plant roots and shoots). The focus for the 2003 meeting will continue to be the molecular and physiological analysis of protein and cellular components needed for different aspects of mechanosensation. The 2005 meeting will continue the exposition of individual mechanotransduction components but will also move toward understanding the complexes of proteins especially critical for the intricate machines that control the tension on mechanosensors. The proposed meetings will bring together scientists who don't normally meet because they study different organisms (microbes, plants, or animals) or different kinds of mechanical responses (rapid responses in specialized mechanosensors or slow responses to sustained forces in bone or plants) or because they employ widely different approaches (genetics vs physiology). Moreover, the Gordon Conference format facilitates informal communications and discussions of controversial issues. These factors will promote inter-disciplinary transfer of ideas and approaches and the forming of new strategies for the study of mechanotransduction.

描述（由申请人提供）：第八和第9个双年展的戈登研究会议“生物系统机械传输和重力信号传导”将于2003年7月20日至25日和2005年7月22日至27日在康涅狄格学院举行。会议的主题是机械感应，一种古老的感官能力。预计约有100名参与者，包括25位演讲者和13位讨论负责人。要求资金支持20名初级参与者。这是对机械敏化研究的激动人心的时刻。该领域正在迅速增长，尤其是在机械转导的遗传方法领域。已经提出了一个非常受支持的模型来解释原核生物机械敏感通道的门控。包括蠕虫和果蝇在内的真核遗传模型系统已经确定了两类推定的机械感知通道，DEG/ENAC和TRP通道，这些通道现在正在直接测试机械门控性能。斑马鱼，小鼠和人类中听力有缺陷突变体的分析正在加速鉴定对毛细胞和听觉功能重要的新蛋白质。除了在专门传感器上工作外，我们对非专业组织（骨骼，植物根和芽）的机械感应的理解还有很大的进步。 2003年会议的重点将继续是对机械敏化不同方面所需的蛋白质和细胞成分的分子和生理分析。 2005年的会议将继续阐明单个机械转导组件，但也将朝着理解蛋白质的复合物迈进，对于控制机械传感器张力的复杂机器特别至关重要。提出的会议将汇集通常不遇到的科学家，因为他们研究了不同的生物（微生物，植物或动物）或不同种类的机械反应（专业机械传感器中的快速反应或对骨骼或植物中持续力的缓慢反应）或使用广泛不同的方法（遗传学与物理学）。此外，戈登会议格式有助于对有争议的问题进行非正式沟通和讨论。这些因素将促进思想和方法的跨学科转移，并形成新的策略来研究机械转移的研究。