Conference on Frontiers of NMR in Molecular Biology

分子生物学核磁共振前沿会议

基本信息

批准号：
6887167
负责人：
Brian Douglas Sykes
金额：
$ 0.5万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-01-01 至 2005-12-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by the applicant): Nuclear Magnetic Resonance (NMR) has a long history of evolving to meet new challenges of molecular biology; this evolution will be and need to be even more rapid in a genomic and post-genomic era. Already the challenge of providing structures of proteins on a genomic scale has produced new NMR approaches for fast structure determination and the prospect of having more targets for the pharmaceutical industry has spawned new NMR based means of screening for molecular interactions. These aspects will place new demands for working with large complex data sets. Further, NMR is expanding into biologically and medically important areas such as integrated systems biology and metabonomics. The realization that biological function often involves the interplay of groups of macromolecules in a dynamic setting demands new methods for monitoring macromolecular interaction in large systems as well as motion in these systems. The advances needed often come from discussions among scientists expert in solid NMR, macromolecular solution NMR, molecular biology and drug discovery. The ultimate challenge for the meeting will be to stimulate discussion among scientists representing these diverse fields. The meeting will be largely organized around new approaches to the challenges defined above and provide a forum for discussion among molecular biologists, NMR spectroscopists, computational biologists, and drug design specialists. The program will be organized around problem areas and integrate talks by scientists having different perspectives on their solution. This will be a timely and innovative meeting in this important field with wide interest and applicability to many areas ranging across fields as diverse as NMR studies of membrane proteins, NMR in integrated systems biology, the study of large proteins and large protein assemblies, new experimental and computational approaches to structural genomics, new methods in biological NMR, including applications of solid-state NMR, the study of motions in proteins and nucleic acids, and the discussion of important new areas where NMR can make especially important contributions such as protein folding and protein folding diseases.

描述（由申请人提供）：核磁共振（NMR）具有悠久的发展历史，可以应对分子生物学的新挑战；在基因组和后基因组时代，这种进化将会而且需要更加迅速。在基因组规模上提供蛋白质结构的挑战已经产生了用于快速结构确定的新 NMR 方法，并且为制药行业提供更多靶标的前景催生了基于 NMR 的新分子相互作用筛选方法。这些方面将对处理大型复杂数据集提出新的要求。此外，核磁共振正在扩展到生物学和医学上的重要领域，例如集成系统生物学和代谢组学。认识到生物功能通常涉及动态环境中大分子团的相互作用，需要新的方法来监测大系统中的大分子相互作用以及这些系统中的运动。所需的进展通常来自固体核磁共振、大分子溶液核磁共振、分子生物学和药物发现领域的科学家之间的讨论。会议的最终挑战将是激发代表这些不同领域的科学家之间的讨论。会议将主要围绕应对上述挑战的新方法进行组织，并为分子生物学家、核磁共振波谱学家、计算生物学家和药物设计专家之间的讨论提供一个论坛。该计划将围绕问题领域进行组织，并整合对解决方案持不同观点的科学家的演讲。这将是这个重要领域的一次及时且创新的会议，具有广泛的兴趣和适用性，涉及膜蛋白的 NMR 研究、集成系统生物学中的 NMR、大蛋白质和大蛋白质组装体的研究、新实验等多种领域。结构基因组学和计算方法、生物核磁共振的新方法，包括固态核磁共振的应用、蛋白质和核酸运动的研究，以及核磁共振可以做出特别重要贡献的重要新领域的讨论，例如蛋白质折叠和核磁共振。蛋白质折叠疾病。