2005 Plant Metabolic Engineering Gordon Res. Conference

2005 植物代谢工程戈登研究中心。

• 批准号: 6931349
• 负责人: ELEANORE T WURTZEL
• 金额: $ 0.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6931349
• 关键词: bioengineering /biomedical engineering; meeting /conference /symposium; metabolism; plant genetics; plant growth /development; travel

DESCRIPTION (provided by applicant): The post-genomic era presents new opportunities for manipulating plant chemistry that will impact the level and nutritional content of the global food supply and lead to new biological sources of novel drugs and therapeutic hormones. The recently approved new Gordon Research Conference (GRC) on Plant Metabolic Engineering will provide a setting for developing multidisciplinary collaborations needed to unravel the dynamic complexity of plant metabolic networks and advance basic and applied research in plant metabolic engineering. The conference will integrate recent advances in genomics, with metabolite and gene expression analyses. Research discussions will explore how biosynthetic pathways interact with regard to substrate competition and channeling, plasticity of biosynthetic enzymes, and investigate the localization, structure, and assembly of biosynthetic complexes in native and nonnative environments. The conference will develop new perspectives for plant transgenic research with regard to how transgene expression may influence cellular metabolism. Incorporation of spectroscopic approaches for metabolic profiling and flux analysis combined with mathematical modeling will contribute to the development of rational metabolic engineering strategies and lead to the evolvement of new tools to assess temporal and subcellular changes in metabolite pools. The conference will also highlight new technologies for pathway engineering, including use of heterologous systems, directed enzyme evolution, engineering of transcription factors and application of molecular/genetic techniques for controlling biosynthetic pathways. The first conference will take place July 10-15, 2005 at the Tilton School, Tilton, New Hampshire and every two years thereafter. Speakers and participants will number approximately 130-150 from the US and abroad, at all career levels, and represent institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will be made for appropriate representation by women, persons with disabilities, and scientists from underrepresented groups.

描述（由申请人提供）：基因组时代为操纵植物化学提供了新的机会，这将影响全球粮食供应的水平和营养含量，并导致新型药物和治疗激素的新生物学来源。最近批准的有关植物代谢工程的新戈登研究会议（GRC）将为开发植物代谢网络的动态复杂性所需的多学科合作提供设置，并推进植物代谢工程中的基本和应用研究。该会议将将基因组学的最新进展与代谢产物和基因表达分析相结合。研究讨论将探讨生物合成途径如何与底物竞争和渠道，生物合成酶的可塑性相互作用，并研究天然和非本地环境中生物合成复合物的定位，结构和组装。关于转基因表达如何影响细胞代谢的植物转基因研究的新观点。与数学建模相结合的用于代谢分析和通量分析的光谱方法的结合将有助于发展理性的代谢工程策略，并导致新工具的发展，以评估代谢物库中时间和亚细胞变化。该会议还将重点介绍用于途径工程的新技术，包括使用异源系统，定向酶演化，转录因子的工程以及用于控制生物合成途径的分子/遗传技术的应用。第一次会议将于2005年7月10日至15日在蒂尔顿学校，新罕布什尔州的蒂尔顿学校举行，此后每两年举行。演讲者和参与者将在各个职业级别的美国和国外的大约130-150人数，并代表来自学术界，工业，私人机构和联邦实验室的机构。妇女，残疾人和代表性不足的群体的科学家将做出一致的努力。